Hi,
Is there a server around somewhere that will examine the sequence of a
protein kinase and tell you which particular subfamily of protein kinase
the sequence presented falls into?
I am thinking particularly of subclassification of tyrosine kinases into:-
1) cytoplasmic or receptor -type
2) specific subclassification (src? abl? InsR? etc.)
Failing this, is there a piece of software around which can be trained to
do this task by feeding it a whole bunch of sequences and telling it which
category they fall into?
While I can identify most tyrosine kinases by inspection, I am not
confident of subclassifying them correctly in this manner, esp. when they
are from invertebrates and may be expected to have diverged to some extent
from the vertebrate homologs. Such a tool would therefore be very useful to
me in trying to place correctly some kinases I have inadvertently cloned.
Thanks,
David Huen, Dept. of Pathology, Univ. of Cambridge
