Kinase classification software/neural net?

David Huen smh1008 at cus.cam.ac.uk
Thu May 25 11:31:59 EST 1995

Is there a server around somewhere that will examine the sequence of a
protein kinase and tell you which particular subfamily of protein kinase
the sequence presented falls into?

I am thinking particularly of subclassification of tyrosine kinases into:-
1) cytoplasmic or receptor -type
2) specific subclassification (src? abl? InsR? etc.)

Failing this, is there a piece of software around which can be trained to
do this task by feeding it a whole bunch of sequences and telling it which
category they fall into?

While I can identify most tyrosine kinases by inspection, I am not
confident of subclassifying them correctly in this manner, esp. when they
are from invertebrates and may be expected to have diverged to some extent
from the vertebrate homologs. Such a tool would therefore be very useful to
me in trying to place correctly some kinases I have inadvertently cloned.

David Huen, Dept. of Pathology, Univ. of Cambridge

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