Recommendations for modeling workstation?

Todd Richmond trichmon at students.wisc.edu
Tue May 16 17:30:18 EST 1995

Hi Netters,

We're in the process of putting together a grant and we'd like to include
a workstation in the proposal.  I'm looking for suggestions for the type
of workstation we should get to do some protein modeling.  I know at one
time the answer would have been a definitive "Silicon Graphics" Is that
still true?  Generally speaking, we want to do protein structure
prediction and receptor-ligand modeling.  All we have at the moment is the
primary sequence and a tentative idea of what the protein structure might
be, based on homology to other known proteins.  Eventually we hope to have
crystal structure as well.  What we'd like to do is make some predictions
now from the amino acid sequence and then play with the structures to see
how known mutations might effect receptor-ligand binding.  Tell me how
reasonable (or unreasonable) this is and what software-hardware
combination you would suggest to accomplish this.  Respond by email or
news - I'll post a summary if I get enough responses.

Thanks in advance,


Todd Richmond                  trichmon at students.wisc.edu
B129 Birge Hall                UW-Madison Dept of Botany      

Knowledge=power=energy=matter=mass; a good bookshop is just
a genteel Black Hole that knows how to read
   - "Guards! Guards!", Terry Pratchett 

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