REGISTRATION INFORMATION
ISMB-95
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The Third International Conference on
Intelligent Systems for Molecular Biology
July 16 - 19, 1995
Robinson College, Cambridge, England
* FULL REGISTRATION MATERIAL AND LIST OF ACCEPTED PAPERS NOW ON WWW *
ftp://ftp.icnet.uk/icrf-public/ismb/ismb95.html
* Date for early registration discount 4th June *
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This file contains:
Description of ISMB-95 Tutorials
ASCII Text form of Registration Form
(See WWW for full registration pack)
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TUTORIALS
All tutorials will be offered on Sunday, July 16. There will be parallel
sessions geared for introductory issues and advanced issues. Tutorial costs
are 50 UKpounds for a single tutorial (65 UKpounds including lunch) and
95 UKpounds for two tutorials (including lunch).
INTRODUCTORY AM TUTORIALS (July 16, 1995, 10.00am - 1.00 pm):
T1 Molecular Biology for the Computer Scientist (Shankar Subramaniam)
A description of the fundamentals of Molecular Biology, specifically
aimed at the computer scientist. Topics to be covered include: the
macromolecules of living systems,nucleic acid structure and
function,protein structure and function, metabolism, energy flows,
evolution and experimental methods in molecular biology.
T2 Intelligent Systems for the Molecular Biologist (Doug Brutlag)
An overview of the intelligent system technologies that have been
applied to molecular biology. Includes knowledge representation,
machine learning, advanced database methods, knowledge-based
simulation, and other techniques. All topics will be taught using
examples from everyday molecular biology research,and this tutorial
is intended to be accessible to biologists without computational
training.
ADVANCED AM TUTORIALS (July 16, 1995, 10.00am - 1.00 pm):
T3 Protein Structure Prediction (Sean O'Donoghue and Burkhard Rost)
A review of the state of the art of computational techniques used
in experimental determination of structure, and in the theoretical
prediction of protein function and 1D, 2D, and 3D structure. Issues
covered include: similarities and differences between the
calculation methods used in deriving structures from X-ray
crystallography and NMR spectroscopy; principles and methods
relevant to closing the gap between known protein sequences and
known structures; methods for testing and validating predicted
structures.
T4 Machine Learning Approaches to Molecular Biology (Pierre Baldi)
A broad overview of the applications of machine learning to
problems in molecular biology. Discussion of statistical induction
and modelling, and its relevance to these methods. Discussion of
the Bayesian framework, Cox-Jaynes axioms, hierarchical modelling,
and model fitting and optimization. The latter portion of the
tutorial will be dedicated to a detailed treatment of Hidden Markov
Models and Stochastic Grammars.
INTRODUCTORY PM TUTORIALS (July 16, 1995, 2.15 pm - 5.45 pm):
T5 Linguistics of Biosequences (David Searls)
Biological sequences viewed as strings in a language. Formal
language theoretic aspects of DNA and protein sequences. Review of
proofs of the positions of biologically relevant languages in the
Chomsky hierarchy, closure properties under biological operations,
and the important role of syntactic ambiguity in genetic material.
Applications of grammar-based approaches to biological sequences,
including syntactic pattern recognition and representation of
inter-and intra-molecular interactions in three-dimensional
structure.
T6 Protein Evolution (Bill Pearson)
This tutorial will present a review of our ability to look back
through evolutionary time using protein sequences and protein
structures. Doolittle's classification of ancient, middle-aged
and modern proteins will be used to examine different modes of
protein evolution, looking both at sequences and structures. The
evidence for and against an informative role for exon structure
will be discussed. Strengths and weaknesses of using similarity
to infer homology, and exploration of the confidence limits that
can be placed on inferences of homology and structural similarity
will be a focus of the tutorial. The statistics of sequence
similarity scores, information content and scoring matrices, and
the strengths and weaknesses in current comparison methods will be
summarized.
ADVANCED PM TUTORIALS (July 16, 1995, 2.15 pm - 5.45 pm):
T7 Computational Methods for Molecular Docking
(Gerhard Klebe,Thomas Lengauer)
Chemical and computational issues in the inference of molecular
docking. Types of chemical interactions, phases of the docking
process, and enthalpic and entropic methods for evaluating docking
potential. Approaches to computing receptor-ligand interactions,
including algorithms, data structures, computationally efficient
models, and validation methods, presented from an
application-oriented viewpoint.
T8 Statistical Foundations of Multiple Sequence Alignment and
Structure Prediction (Chip Lawrence)
The significance of statistical methods for multiple sequence
alignment, and their conceptual foundations. Boltzman-like models
of residue frequencies, permuted data likelihood, expectation
maximization and Gibs sampling. Refinements in the method to
include multiple elements (gaps) and manage the flexibility vs.
sensitivity tradeoff. Incorporating structure into the
calculation, including protein threading and stochastic context
free grammars for RNA alignment.
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ISMB-95 REGISTRATION FORM
NAME: ..............................................................
AFFILIATION: ..............................................................
.............................................................
ADDRESS: .............................................................
.............................................................
............................................................
PHONE: ............................. FAX: ...............................
E-MAIL: .....................................................................
Are you:- Full-time Student* ...... Other ......
Male ...... Female ......
* Please include proof of full-time student status
...... Tick here if you would like information about travel support
TUTORIALS
(select at most one tutorial from each column)
AM ...... PM ......
AM 16/7: PM 16/7:
T1: Molecular Biology for the T5: Linguistics of Biosequences
Computer Scientist T6: Protein Evolution
T2: Intelligent Systems for the T7: Computational Methods for
Molecular Biologist Molecular Docking
T3: Protein Structure Prediction T8: Statistical Foundations of
T4: Machine Learning Approaches Multiple Sequence Alignment
to Molecular Biology and Structure Prediction
ONE TWO
50 UKpounds/$85/65ecu 95 UKpounds/$155/125ecu
(or 65 UKpounds/$110/85ecu (including lunch)
including lunch)
UKpounds/$/ecu ......
CONFERENCE REGISTRATION
Early* Late
Full-time student* 125 UKpounds/$200/160ecu 150 UKpounds/$240/195ecu
Other 150 UKpounds/$240/195ecu 175 UKpounds/$280/225ecu
UKpounds/$/ecu ......
* Early registration = before 4 June 1995
ACCOMMODATION/MEALS
Accommodation Package @ 260UKpounds/$420/330ecu UKpounds/$/ecu ......
Extra Night's Accommodation (B&B) @ 50 UKpounds/$85/65ecu per night
(Pre-Tutorial: 15 July Post-Conference: 19 July)
Please specify date(s) .............. UKpounds/$/ecu ......
Non-Residential
Lunch only @ 15 UKpounds/$25/20ecu per day (17, 18 and 19 July)
Please specify date(s ) ............. UKpounds/$/ecu ......
Conference Dinner tickets @ 35 UKpounds/$60/50ecu UKpounds/$/ecu ......
TOTAL UKpounds/$/ecu ......
I enclose my cheque/money order (UKpounds, $US, ecus - please specify)
made payable to Imperial Cancer Research Fund (ISMB-95)
or debit my card: Access/Visa/Amex/Diners Club (please specify)
Card No: Expiry Date:
Signed: Date:
Please list:-
Any special dietary requirements
..............................................................
Any special accommodation requirements (eg twin room)
..............................................................
Whether wheelchair access is required
..............................................................
Please state if you would like to present a poster at the
Open Poster Evening - to be held on Tuesday July 18, 6.00pm - 7.30pm
Yes/No
Return Registration Form with payment to:-
ISMB-95 Registration
c/o Dr C J Rawlings
Biomedical Informatics Unit
61 Lincoln's Inn Fields
LONDON WC2A 3PX
Fax: + 44 (0)171 269 3067
