bionet at cgmvax.cgm.cnrs-gif.fr wrote:
: >This is much too pesimistic. About one third of all currently known
: >sequences are related to at least one currently known structure.
: ??? You really mean that 15,000 sequences from Swissprot (for example) are
: related to at least one entry in the PDB ? I'd be interested in getting a
: reference on this subject.
There are plenty of references on the subject, they basicly stem from the
fact that the number of different folds seems to be relatively low (estimates
vary from 100 to 1000).
The analysis of the gene sequences of one of the yeast's chromosomes by Sander's
group demonstrates this point very clearly.
Of course ther is a problem in the vias of the PDB, but it seems clear now that
protein modeling by homology has a very strong 'raison d'etre'.