Get Macaw from the NCBI for Windows or Macs.
Excerpts from the README.TXT file:
MACAW is a program for locating, analyzing, and editing blocks of localized
sequence similarity among multiple seqences and linking them into a
composite multiple alignment.
REFERENCES
Gregory D. Schuler, Stephen F. Altschul, and David J. Lipman (1991). A
Workbench for Multiple Alignment Construction and Analysis. Proteins
Struct. Funct. Genet. 9, 180-190.
Charles E. Lawrence, Stephen F. Altschul, Mark S. Boguski, Jun S. Liu, Andrew
F. Neuwald, and John C. Wootton (1993). Detecting Subtle Sequence
Signals: A Gibbs Sampling Strategy for Multiple Alignment. Science 262,
208-214.
Samuel Karlin and Stephen F. Altschul (1990). Methods for Assessing the
Statistical Significance of Molecular Sequence Features by Using General
Scoring Schemes. Proc. Natl. Acad. Sci. USA 87, 2264-2268 (1990)
FTP DOWNLOADING INSTRUCTIONS
The program is available for the Macintosh and several flavors of
Microsoft Windows. All of them may be downloaded from NCBI's anonymous
FTP server (ncbi.nlm.nih.gov). Each version is stored in a seperate
directory as described below.
pub/macaw/win16
This directory contains the 16-bit version of MACAW for Windows 3.1x and
Windows for Workgroups 3.1x. The file macawz.exe should be downloaded
in binary mode.
pub/macaw/win32-intel
This directory contains the 32-bit version of MACAW for systems based on
the Intel family of processors. It requires either Windows NT or a DOS-hosted
version of Windows that also has the Win32s subsystem installed.
The file macawz.exe should be downloaded in binary mode.
pub/macaw/win32-alpha
This directory contains the 32-bit version of MACAW for systems based on
the DEC Alpha AXP processor and running Windows NT. The file macawz.exe
should be downloaded in binary mode.
pub/macaw/mac-68k
This directory contains the version of MACAW for Macintosh systems based on
the 680x0 family of processors, but also runs on PowerMacs under emulation.
The file macaw.sea.hqx (HexBin format) should be downloaded to your mac.
Many Mac FTP programs automatcally convert HexBin files, so you will end
up with a file called macaw.sea. If you do not have such a program, you
will need to perform HexBin conversion yourself using a utility such as
Stuffit or Compactor.
