Software for comparing sequence homology from GenBank server?

Brian Foley brianf at med.uvm.edu
Wed Nov 2 17:03:57 EST 1994

Jason L. Buberel (jbuberel at uiuc.edu) wrote:
: Could someone please let me know if there is a simple (straighforward) way
: to ask GenBank (or a similar service) to compare sequence homology for me
: if I give it the names of several related genes (or same gene between
: different species).  We are trying to find conserved areas among the
: cytochrome enzyme genes.  We have played with the GenBank web site,

	If you have a WWW browser, you should find out more about 
ENTREZ.  The ENTREZ service is now available on the web:


	You have to register your machine (IP address) to get full
function from Netwrok-ENTREZ or WWW-ENTREZ, but once you do, you
will have a world of info at your fingertips.

	ENTREZ has not only gene and protein sequences, but also a 
large subset of medline (articles pertaining to genes and proteins
are there, clinical trials and such are not).  
	ENTREZ also has a VERY POWERFUL "neighboring" function.
NCBI has already compared every sequence to every other one, so if
you select a gene, protein or medline abstract and click the
"neighbors" button, ENTREZ will show you the other genes, proteins
or abstracts that are most similar to the one you selected.

*  Brian Foley               *     If we knew what we were doing   *
*  Molecular Genetics Dept.  *     it wouldn't be called research  *
*  University of Vermont     *                                     *

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