Software for comparing sequence homology from GenBank server?

Jonathan Epstein epstein at gold.nlm.nih.gov
Thu Nov 3 09:18:19 EST 1994

Brian Foley (brianf at med.uvm.edu) wrote:
> Jason L. Buberel (jbuberel at uiuc.edu) wrote:
> : Could someone please let me know if there is a simple (straighforward) way
> : to ask GenBank (or a similar service) to compare sequence homology for me
> : if I give it the names of several related genes (or same gene between
> : different species).  We are trying to find conserved areas among the
> : cytochrome enzyme genes.  We have played with the GenBank web site,

> 	If you have a WWW browser, you should find out more about 
> ENTREZ.  The ENTREZ service is now available on the web:

> http://www.ncbi.nlm.nih.gov/Search/Entrez/index.html

> 	You have to register your machine (IP address) to get full
> function from Netwrok-ENTREZ or WWW-ENTREZ, but once you do, you
> will have a world of info at your fingertips.

Thanks for pointing out this information, Brian.  I want to clarify,
though, that registration is _not_ required to use WWW-Entrez, although
it is required for Network Entrez.  Information regarding both of these
services, as well as the Entrez CD-ROM is available by following the
"Entrez Browser" hypertext link from the above WWW page.

Information about Network Entrez is also available by viewing the file
ftp://ncbi.nlm.nih.gov/entrez/network/README or by writing to
net-info at ncbi.nlm.nih.gov.

> 	ENTREZ has not only gene and protein sequences, but also a 
> large subset of medline (articles pertaining to genes and proteins
> are there, clinical trials and such are not).  
> 	ENTREZ also has a VERY POWERFUL "neighboring" function.
> NCBI has already compared every sequence to every other one, so if
> you select a gene, protein or medline abstract and click the
> "neighbors" button, ENTREZ will show you the other genes, proteins
> or abstracts that are most similar to the one you selected.

> --
> ********************************************************************
> *  Brian Foley               *     If we knew what we were doing   *
> *  Molecular Genetics Dept.  *     it wouldn't be called research  *
> *  University of Vermont     *                                     *
> ********************************************************************

- Jonathan

Jonathan Epstein                                epstein at ncbi.nlm.nih.gov
National Center for Biotechnology Information   Phone: (301)496-2475
National Library of Medicine                    Building 38A, Room 8N805
National Institutes of Health                   8600 Rockville Pike
                                                Bethesda, MD 20894

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