Homologous Vertebrate Genes Data Base
Release 6 (May 9 1994)
from GenBank Release 82 (April 15 1994)
The new release is available by anonymous FTP at
in the directory
HOVERGEN is a database of homologous vertebrate genes. HOVERGEN allows one to
easily select sets of homologous genes among a given set of vertebrate species.
HOVERGEN corresponds to all nuclear vertebrate sequences of
GenBank, with some data corrected, clarified, or completed, notably to address
the problem of redundancy. Coding sequences have been classified in gene
families. Protein multiple alignments and phylogenetic trees have been
calculated for each family.
Sequences and related information have been structured in an ACNUC
database. A program named "query" allows to make complex selections in the
ACNUC database according to any information clearly declared (keywords,
bibliography, taxonomy, etc.). Selection criteria can be combined with boolean
A graphical interface has been developed to visualize and edit trees.
Genes are displayed in color, according to their taxonomy. Users have directly
access to all information attached to sequences (either from GenBank or specific
of HOVERGEN), or multiple alignments simply by clicking on genes. This graphical tool gives thus a rapid and simple access to all data necessary to interpret
homology relationships between genes: phylogenetic trees of gene families,
taxonomy, GenBank information and protein multiple alignments.
HOVERGEN is particularly useful for:
- comparative sequence analysis
- molecular evolution studies
More generaly, HOVERGEN gives an overall view of what is known about
a particular gene family.
Laboratoire de Biometrie, Genetique et Biologie des Populations
URA CNRS 243 Universite Claude Bernard - Lyon I
43, Bd du 11 Novembre 1918 F-69622 Villeurbanne cedex
Tel: +33 18.104.22.168
E-mail: duret at biomserv.univ-lyon1.fr