Here's a summary of responses I've received to my "what's the best
pharmacokentics software out there" posting.
Many thanks to all who took the time to respond!
Summary: There aren't many programs out there for PK novices -- most seem
to
require some expertise in nonlinear regression techniques and the ability
to code models in FORTRAN.
I'll keep this summary up to date if anyone sends me any corrections or
updates. I'll repost to bionet.software periodically.
Vernon Keenan
BioData, Inc.
Internet: vern at biodata.com
1825 South Grant Street, Suite 620
San Mateo, CA 94402
Voice: 415-513-8950
-----------------------------------------
From: mhamiltn%dres.dnd.ca (Dr. Murray G. Hamilton)
>Software For Science catalog (SciTech
>International - call 1-800-622-3345 for a free copy of the catalog) of a
>product called MINSQ and MINSQ Pharmacokinetic Library.
This number does not work from Canada. Could you please E-mail a
"real" number to me. Thanks in advance.
Murray
*************************************************************************
**** The non-800 number for SciTech International is +1 312-472-0444 ****
*************************************************************************
- Vern
-----------------------------------------
From: christo1 at fmi.ch (Christen Tobias)
I would highly appreciate a summary! Thanks!
In wuarchive.wustl.edu there is kinsim a tool for the mac (rather low
level but flexible..) it is in the directory /packages/kinsim
Cheers and thank you for the summary
Toby
-----------------------------------------
From: GEXFABRY at cmu.unige.ch (Marianne Gex-Fabry)
I recently made a survey of software packages available for analysis
of pharmacokinetic data. More than 40 products have been cited to me,
mostly for IBM compatible PCs. A complete list of these products,
together with information about how to obtain them, is being sent to
you by normal mail.
Please note that the list together with a general discussion of features
and requirements of the different products will be part of a chapter
entitled "Considerations on data analysis using computer methods and
currently available software for personal computers" by M. Gex-Fabry
and L.P. Balant, to be published soon in "Handbook of Experimental
Pharmacology", volume 110 "Pharmacokinetics of drugs" (Welling and Balant,
eds), Springer, Berlin.
With best regards, Marianne Gex-Fabry
-----------------------------------------
From: ahb at gene.com (Ann Benninger)
We use NONLIN84 from SCI Software in Lexington KY. It
is available on IBM compatibles and in 2 source (fortran)
versions; for VMS and a 'portable' version. I'm using
the VMS specific version on our UNIX machines because the
portable version is pretty lean. NONLIN84 is inexpensive
and it is standard. Check out BIOPAK from the same vendor.
A less standard program is available from USC and is
called ADAPT. It is also in fortran and distributed
in source. I think there's a SUN version in addition
to the VMS version.
C D. Z. D'Argenio, Biomedical Simulations Resource (BMSR) *
C University of Southern California *
C Los Angeles, California 90089-1451 *
Note: to use ADAPT, the PK group needs to have at least
one person who's comfortable writing fortran subroutines
to describe the PK models.
- Ann
-----------------------------------------
From: DOSIO at silver.ch.unito.it (Franco Dosio)
Dear Vernon,
to obtain a (complete) list of available pharmacokinetic software, try to
NISS bbs. At sun.nsf.ac.uk (pass. janet) host: uk.ac.niss.bb
In the directory P8B7.
To analize the pharmacokinetic data of MAb, toxin and drugs I'm using
Pcnonlin 4.0 (SCI software, Lexington, Kentuky, tel 606-224-2438) and
it works fine, but it runs only on PC or Vax.
Regards
Franco Dosio
Ist. Chim.Farm.Applicata
University of Turin, Italy
DOSIO at silver.ch.unito.itU196CFA at csivms.csi.it
*************************************************************************
**** Here is the catalog Franco was talking about! ****
*************************************************************************
To get access to this bulletin board do this:
telnet sun.nsf.ac.uk
user janet
pass janet
Hostname: uk.ac.niss.bb
- Vern
PHARMACOKINETICS SOFTWARE CATALOGUE
Title: Boomer and MultiForte
Subject Area: Pharmacokinetics
Description: Non-linear regression programs for the
Macintosh and IBM PC. Weighted non-linear regression,
simulations, Bayesian analysis, and Iteratively Reweighed
Least Squares analyses are possible. In MultiForte models
are specified by modifying model definition subroutines in
FORTRAN. In Boomer the model is defined by the selection
of parameters such as dose, first-order rate constant, volume
etc. Integrated and differential equation type models are
possible. Fitting algorithms include Gauss-Newton,
Marquardt, and simplex. Numerical integration routines
include Runge-Kutta, Runge-Kutta-Fehlberg, and Gears
Section P8B7 Page 2
of 14
Hardware: Macintosh and IBM PC
Contact: David Bourne OU HSC College of Pharmacy, 1110 N
Oklahoma City, OK 73117-1223, USA Tel (405) 271-6471
david-bourne at uokhsc.edu
Cost:40 dollars for Mac version Source: D. Bourne
Section P8B7 Page 3
of 14
Title: Pharmacokinetics Simulation
Subject Area: Pharmacokinetics
Description: Simulation software written for the Apple II
computer. Students select model type, input plot
descriptions input parameter values and the computer
presents a linear or semi-log plot of the calculated
values. With appropriate printer hard copy is available.
Written in AppleSoft BASIC. Models include one or two
compartment pharmacokinetic models, single and mutiple
dose. Only integrated equation models are included in the
Apple II version
Section P8B7 Page 4
of 14
Hardware: Apple IIe being ported to the Macintosh (68020+)
Contact: David Bourne, OU HSC College of Pharmacy, 1110 N
Oklahoma City, OK 73117-1223 USA Tel:(405) 271-6471
david-bourne at uokhsc.edu
Cost: Distribution Only Source: D. Bourne
Section P8B7 Page 5
of 14
Title: Kinetics Workshops
Subject Area: Pharmacokinetics
Description: Workshops to compliment pharmacokinetics
undergraduate course self assesment style.
Hardware: BBC Software
Contact: Dr H Crystyn Pharm Technology School of Pharmacy
Bradford University Bradford UK Tel 0279 733466
Extn 558
Cost: 50 pounds Source: DIT
Section P8B7 Page 6
of 14
Title: Pharmod
Subject Area: Pharmacokinetics
Description: Powerful but very friendly pharmacokinetic
modeling program. Models 2 different pharmacokinetic
situations including linear and non linear elimination.
Sample tutorial and demonstration disc available.
Hardware: IBM compatable PC
Contact: Dr P H Rowe Health Sciences Liverpoll Poly Byrom
Street Liverpool UK Tel 051 207 3581 Ext 2069
Cost 200 pounds Source: DIT
Section P8B7 Page 7
of 14
Title: Maxsim
Subject Area: Pharmacokinetics
Description: Pharmacokinetics simulation
Hardware: IBM-compatable PC
Contact: Gabrielsson Biopharmaceutics & Pharmacokinetics
Box 580, BMC S-75123 Uppsala Sweden
Cost: 70 pounds Source: DIT
Section P8B7 Page 8
of 14
Title: Mupharm - Human Drug Kinetics
Subject Area: Pharmacokinetics
Description: Simulation program in Pharmacokinetics
Hardware: IBM-compatable PC
Contact: IRL Press Oxford University Press Eynsham Oxford
Cost: 100 pounds approx Source: DIT
Section P8B7 Page 9
of 14
Title: MacDope
Subject Area: Pharmacokinetics
Description: Computer simulation of pharmacokinetics which
enables patient factors and drug factors to be changed.
Changes are reflected in drug concs. in biological fluids.
Hardware: Mainframe computer
Contact: Dr D Ingram Dept of Medicine St Bartholomews
West Smithfield London UK
Cost: Source: DIT
Section P8B7 Page 10
of 14
Title: ADAPT II
Subject Area: Pharmacokinetics
Description: Non-linear regression programs for the
VAX/VMS, DOS, or SUN/UNIX. Models are specified using
FORTRAN statements. Requires a FORTRAN compiler as each
model is recompiled before use. Simulation can be error free
of with noise or based on population values. Uses the LSODA
method for numerical integration (which is suitable for non-
stiff and stiff problems). The program will perform simplex
optimization, maximum likelihood and Bayesian fitting or
will develop optimal sampling designs.
Hardware: VAX/VMS, DOS, or SUN/UNIX
Contact: David Z. D'Argenio, Biomedical Simulations
Resource, University of Southern California, Los Angeles
CA 90089-1451, USA Tel (213) 740-0839
Cost: Free (in U.S.) Source: D. Bourne
Section P8B7 Page 12
of 14
Title: NONMEM
Subject Area: Pharmacokinetics
Description: Computer prgram for fitting nonlinear mixed
effects (statistical regression-type) models. These
techniques are particularly useful where the data are
population pharmacokinetic data and when there are few
measurements from each subject and/or the variation between
subjects is considerable.
Hardware: Computer capable of compiling FORTRAN77 code, but
workstation, mainframe recommended.
Contact: Dr Stuart Beal, The NONMEM Project Group, Clinic-255,
University of California, CA 94143 USA
Cost: Academic US$150 per year Source: D. Bourne
Section P8B7 Page 13
of 14
Title: SAAM30 and CONSAM
Subject Area: Pharmacokinetics
Description: Computer programs for performing non-
linear regression analysis. Models are specified by
means of various parameters or free-form equations.
SAAM30 is operated in batch mode while CONSAM is more
interactive. Numerical integration routines are available
non-stiff and stiff systems.
Hardware: VAX/VMS and DOS
Contact: Loren A. Zech, M.D., N.I.H./NCI, Laboratory of
Mathematical Biology, MD 20892 USA Tel (301) 496-8914
Cost: Free (in U.S.) Source: D. Bourne
Section P8B7 Page 14
of 14
Title: Pharmacokinetics
Subject Area: Pharmacokinetics
Description: CAL porgrams in pharmacokinetics
Hardware: (1) BBC (2) IBM-compatable PC
Contact: (1) Alan Kensley (2) Dr Foster, Dept of Pharmacy
Manchester University Manchester UK Tel: 061 2752340
Cost: Source: DIT
***************************************************************
| Vernon Keenan | Voice: 415-513-8940 |
| President | Fax: 415-312-8086 |
| BioData, Inc. | Internet: vern at BioData.COM |
| 1826 S. Grant St. Suite 620 | |
| San Mateo, California 94402 | |
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