plasmid maps from rest. frag. sizes?

rybicki at uctvax.uct.ac.za rybicki at uctvax.uct.ac.za
Wed Sep 30 09:43:20 EST 1992

In article <BRIANF.92Sep21172418 at dna.uvm.edu>, brianf at dna.uvm.edu (Brain Foley) writes:
> 	I am looking for a program (Mac, DOS, or VMS) that will help
> me draw a circular (or linear) map of DNA, given a list of the
> restriction fragment sizes that are observed upon single and
> multiple-enzyme digests.
> 	I have looked in the IBMPC and MAC subdirectories of the
> MOLBIO directory of FLY.BIO.INDIANA.EDU FTP site.  I did not see what
> I wanted there, but I may have missed something.

I must heartily recommend a package called RESOLVE for PC, available from Prof.
Eric Harley, UCT Medical School, PO Observatory 7925, South Africa (or, more
obviously for this forum, harley at chempath.uct.ac.za or @uctvax.uct.ac.za). 
This assists in mapping in that it tells you when the (or a) map is obtainable
from the data; it also tells you how MANY maps can be made from the same data
given different errors in measurement of band size!  It can be used as a map
database, and even to compare any number of maps in terms of phylogenetically
informative sites, or proportion of sites shared.  Costs US$100 from him
direct (I have no interest, I just like the package).
|                                 |                                       |
|  Ed Rybicki                     |    Now you've got the hang of it      |
|  Dept Microbiology              | There's nothing you can't do with it  |
|  University of Cape Town        |         If you're very into it        |
|  PB Rondebosch 7700             |         You can't go wrong....        |
|  South Africa                   |                                       |
|  fax 27 21 650 4023             |              - Mad John               |
|  ed at micro.uct.ac.za             | (Ogden's Nut-Gone Flake, Small Faces) |

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