This is an annoucement for the public release of a WINDOWS 3.x based program
to analyze the GENETIC STRUCTURE OF POPULATIONS using MOLECULAR INFORMATION.
This program (WINAMOVA ver 1.04) is based on a paper by Excoffier, Smouse and
Quattro (1992), and computes variance components for 2 levels of population
structure as well as their associated modified F-statistics (called here Phi-
statistics).
This version can handle a maximum of 255 molecular haplotypes, 100 populations
and 100 groups of populations. It requires haplotype frequency information for
each population, as well as a matrix of inter-haplotypic squared (euclidian)
distances.
Conventional multi-allelic F-statistics may also be computed.
The program includes a non-parametrical (permutational) test for the
significance of both variance components and Phi-statistics.
It can be uploaded by anonymous FTP from : ACASUN1.UNIGE.CH
(username : anonymous) in the directory : pub/amova
under the form of an archived file called WINAMOVA.ZIP, including
executable versions for Windows 3.0 and Windows 3.1, plus example files.
The program is FREEWARE and can be distributed freely in its
original form, but I would appreciate receiving an E-mail from
interested users, as well as comments, suggestions, and bug
reports.
(Windows 3.x is a product from Microsoft Corporation)
Reference cited :
=================
Excoffier, L, Smouse, PE, and Quattro, JM (1992) Analysis of molecular variance
inferred from metric distances among DNA haplotypes: Application to human
mitochondrial DNA restriction data. Genetics 131:479-491.
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* *
* Laurent Excoffier *
* Genetics and Biometry Laboratory Tel : 41-22-343.69.30 *
* Dept. of Anthropology and Ecology *
* University of Geneva Fax : 41-22-300.03.51 *
* 12, rue Gustave Revilliod *
* 1227 Carouge-Geneva, Switzerland E-mail : excoffie at sc2a.unige.ch *
* *
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