Brian Robertson (robertson at mpib-tuebingen.mpg.dbp.de)
Message-Id: <9210201308.AA09871 at net.bio.net>
asks---
>Does anyone know of any software for the prediction of T-cell epitopes from
>peptide sequences?
Amphi does a descent job of this. See _The_Journal_of_Immunology_ (1987)
138:2213-2229 (Margalit, et al.) "Prediction of immunodominant helper T cell
antigenic sites from primary sequence". We have it running on a VAX and it
works pretty well. The algorithm is based on amphipathic helix prediction.
Source code is included in the article's appendix.
Steve Thompson
Steven M. Thompson
Consultant in Molecular Genetics and Sequence Analysis
VADMS (Visualization, Analysis & Design in the Molecular Sciences) Laboratory
Washington State University, Pullman, WA 99164-1224, USA
AT&Tnet: (509) 335-0533 or 335-3179 FAX: (509) 335-0540
BITnet: THOMPSON at WSUVMS1 or STEVET at WSUVM1
INTERnet: THOMPSON at wsuvms1.csc.wsu.edu
