T-cell epitope prediction

Steve Thompson: VADMS genetics THOMPSON at WSUVMS1.CSC.WSU.EDU
Tue Oct 20 10:04:33 EST 1992

Brian Robertson (robertson at mpib-tuebingen.mpg.dbp.de)
Message-Id: <9210201308.AA09871 at net.bio.net>

>Does anyone know of any software for the prediction of T-cell epitopes from
>peptide sequences?

Amphi does a descent job of this.  See _The_Journal_of_Immunology_ (1987)
138:2213-2229 (Margalit, et al.) "Prediction of immunodominant helper T cell
antigenic sites from primary sequence".  We have it running on a VAX and it
works pretty well.  The algorithm is based on amphipathic helix prediction. 
Source code is included in the article's appendix.

						Steve Thompson

                              Steven M. Thompson
            Consultant in Molecular Genetics and Sequence Analysis
VADMS (Visualization, Analysis & Design in the Molecular Sciences) Laboratory
           Washington State University, Pullman, WA 99164-1224, USA
          AT&Tnet:  (509) 335-0533 or 335-3179  FAX:  (509) 335-0540
                  BITnet:  THOMPSON at WSUVMS1 or STEVET at WSUVM1
                   INTERnet:  THOMPSON at wsuvms1.csc.wsu.edu

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