Wondering about software to treat the Double-Digest Problem

Thu May 14 13:48:24 EST 1992

Greetings! Can somebody out there in Bionetland tell me if publicly 
accessible software exists for handling Double- or Multiple-Digest 

I am aware that these are difficult computational problems, pretty 
much intractable, for a number of reasons. However, I have a user 
facing fairly "small" instances of DDP/MDP, and he could be aided by 
some automated form of attack, accepting that suggested solutions 
might come with no guarantee of correctness or optimality.

We would also be interested in hearing about public-domain software 
which could assist the planning of successive digests for purposes 
of restriction mapping, that is, a tool which could compute and 
somehow highlight remaining ambiguities in restriction site order.

Note: I am not a subscriber to this group so please reply to me 
directly. Thanks in advance for any help!

	Mark Reboul
	Columbia University Cancer Center Computing Facility
	mark at cuccfa.ccc.columbia.edu

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