Dear all,
Many thanks to those who tried out the first test drive of PROSITE on
WAIS. Initially, two source files had to be used. I have now merged
the two so that you get all in one source file : prosite.src. Please
delete the prosite-list.src. The old prosite.src may still be usable
but best cut out the new prosite.src and stick it in your /wais-sources
directory minus this note. The prosite.src has been edited to include
some more information (5K now) and some hints on how to use the source
WAISly :-). I have registered the source with think.com.
Many thanks to our early users, and to Rob Harper who tested out the
first version, and of course to Amos Bairoch for allowing it to be
used in this way.
Hope you find it useful.
Tin Wee TAN and Derek Kiong. (bchtantw at nuscc.nus.sg
************************* PROSITE on WAIS *****************************
-------cut out this line and all above,saving this file in /wais-sources ------
(:source
:version 3
:ip-address "137.132.3.3"
:ip-name "solomon.technet.sg"
:tcp-port 210
:database-name "prosite"
:cost 0.00
:cost-unit :free
:maintainer "waisguy at solomon.technet.sg"
:description "
Server created with WAIS release 8 b3.1 on
Feb 8 17:35:37 1992 by waisguy at solomon.technet.sg
The files of type dash used in the index were:
/home/waisguy/src/prosite-db
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PROSITE: A DICTIONARY OF PROTEIN SITES AND PATTERNS
USER MANUAL
Release 8.00, December 1991
Amos Bairoch
Medical Biochemistry Department
Centre Medical Universitaire
1211 Geneva 4
Switzerland
Telephone: (+41 22) 61 84 92
Electronic mail address: bairoch at cgecmu51.bitnet
or bairoch at cmu.unige.ch
The use of protein sequence patterns (or motifs) to determine the
function(s) of proteins is becoming very rapidly one of the essential
tools of sequence analysis. This reality has been recognized by many
authors including well known experts of protein sequence analysis, R.F.
Doolittle and A.M. Lesk.
PROSITE is a compilation of sites and patterns found in protein sequences.
Some of these patterns been published in the literature, but the majority
have been developed, in the last two years, by the author. Originally this
dictionary was conceived as part of the author's doctoral dissertation as
well as an integral part of the PROSITE program in the PC/Gene sequence
analysis software package. But, as many people have expressed their
interest in this project, we have decided to make this work available on
computer media as well as in a printed form.
If you want to refer to PROSITE in a publication you can do so by citing:
Bairoch A.
PROSITE: a dictionary of sites and patterns in proteins.
Nucleic Acids Res. 19:2241-2245(1991).
This release of PROSITE contains 530 documentation entries that describe
605 different patterns including:
Post-translational modifications Electron transport proteins
Domains Other transport proteins
DNA or RNA associated proteins Structural proteins
Enzymes Receptors
Oxidoreductases Cytokines and growth factors
Transferases Hormones and active peptides
Hydrolases Toxins
Lyases Other proteins
Isomerases
Ligases
Other Enzymes
This WAIS source of the PROSITE dictionary has been created with the
permission of Dr Amos Bairoch by Dr Tin Wee TAN, Dept of Biochemistry,
(INTERNET: bchtantw at nuscc.nus.sg BITNET: bchtantw at nusvm.bitnet) and
Dr Derek Kiong, Dept of Information Systems and Computer Science
(isckbk at nuscc.nus.sg) National University of Singapore, Kent Ridge,
Singapore 0511, and maintained on the Singapore TECHNET Unix at
solomon.technet.sg (137.132.3.3).
Newcomers are advised to use the keywords 'PROSITE' or 'help' or
'documentation' to find out more about the PROSITE dictionary. (Please
see the section below on 'Additional Hints'.)
For a list of where you can obtain the PROSITE database, please use
the keywords 'obtain' or 'get'.
For a list of software/programs that make use of PROSITE, please use
the keywords 'software' or 'program'.
For a detailed explanation of how this source was indexed, use the
keyword 'WAISINDEX' to retrieve the entry or consult
bchtantw at nuscc.nus.sg or isckbk at nuscc.nus.sg. Comments are warmly
welcomed.
For questions relating to the content of the PROSITE dictionary,
you are requested to direct your queries to the copyright author
of PROSITE, Dr Amos Bairoch (address given above).
The entire database or entries within the database may be copied and
redistributed freely, without advance permission, provided that its
textual content is not modified.
ADDITIONAL HINTS for getting the best out of this WAIS service.
---------------------------------------------------------------
1) Use as wide a term for an initial search. Eg if looking for
chymotrypsin, start with protease.
2) Be careful when using the PDOC numbers. Note that the O is not the
same as 0.
3) Because of the indexing software, keyword chymotrypsin may not
pick up entries without the exact word chymotrypsin, even though
the word chymotrypsins may be present.
4) To understand the way the way the entries are structured, read the
PROSITE documentation (keywords PROSITE documentation help).
"
)
--
Tin Wee TAN, PhD. / INTERNET: bchtantw at nuscc.nus.sg
Dept of Biochemistry / BITNET: BCHTANTW at NUSVM
National Univ. of Singapore / Tel: 772-3678
SINGAPORE 0511 / Fax: 779-1453
