Software for calculating pI?

rpgrant at vax.path.ox.ac.uk rpgrant at vax.path.ox.ac.uk
Fri Dec 4 10:02:38 EST 1992

In article <1992Dec3.145158.6678 at cs.nott.ac.uk>, mbxfd at mips.nott.ac.uk writes:
>  Hello,
>    Does anybody know of software to calculate the pI of peptides?

In article <robison1.723400976 at husc10>, robison1 at husc10.harvard.edu
>       The GCG program PeptideSort will do this

GCG also has ISOELECTRIC, which draws a rather nice plot of charge against pH, 
so you can make an intelligent guess at appropiate pH values to do your ion 
exchange (IEX).
	As far as I know, it is not possible to correct for secondary 
structure (although I'd love to be proved wrong).

Richard Grant
rpgrant at vax.path.ox.ac.uk

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