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Postdoctoral position available in Miami

Gennaro D Urso gdurso at miami.edu
Wed Jun 4 13:03:55 EST 2003

Postdoctoral Position Available




Applications are invited for a NIH funded post-doctoral position to begin
asap in the laboratory of Dr. Gennaro D¹Urso, in the Department of
Biochemistry and Molecular Biology at the University of Miami School of
Medicine.  This group studies the role of DNA polymerase epsilon in DNA
replication initiation, and the checkpoint controls that are activated when
DNA replication initiation is blocked.  The project will focus on the
characterization of rid mutants that are defective in DNA replication
initiation.  When grown at the semi-permissive temperature these mutants
activate a Chk1-dependent, Cds1-independent checkpoint that delays cell
cycle progression and is essential for cell viability (Feng and D¹Urso,
2001, MCB 21, p.4495).  We propose to determine the nature of DNA
replication defect in these mutants, identify the components necessary for
checkpoint signaling, and to address whether these mutants have an elevated
mutation rate. We have also observed that many of these mutants display
increased ROS production and annexinV staining, suggesting that a high
percentage of these cells are undergoing programmed cell death (PCD).  We
are currently testing the hypothesis that disruption of the replication
initiation complex in these mutants not only activates a checkpoint control,
but may also trigger an apoptotic-like pathway.  This work will contribute
to our basic understanding of how DNA replication initiation is regulated,
and how defects in DNA replication initiation may be coupled to both
checkpoint activation and programmed cell death.

Candidates should be highly motivated and enthusiastic, capable of thinking
and working independently, with experience in one or more aspects of
molecular biology, biochemistry or genetics.  Candidates applying for the
Postdoctoral Fellowship should have or expect to obtain a PhD in a related
subject. These positions will be for at least 3 years with the possibility
of an extension. Salary will closely follow NIH guidelines and will depend
on age and experience.

The laboratory is located in Miami, within close proximity to Miami Beach
and other local attractions.  Laboratories are well equipped and are
supported by an effective infrastructure within the University with many
opportunities for collaboration in the areas of cell and cancer biology.
Further information about the University of Miami can be found at

Candidates should submit a full C.V., including the names and addresses of
two referees, to Gennaro D¹Urso, University of Miami School of Medicine,
Dept of Biochem and Mol Biol, P.O. Box 016129, Miami, FL 33101-6129, or by
email to gdurso at miami.edu.

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