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What's essential?

SLF notmyaddress at hotmail.com
Wed Sep 26 12:49:39 EST 2001

> Wenyi writes,
> Dear yeast community,
>     I have a what might appear to be galactically stupid question: is
> MEC1 essential for viability in budding yeast? I have seen different
> reports and am genuinely confused. I'd appreciate it if someone could
> explain to me.

MEC1 is indeed essential.  However, its lethal phenotype can be suppressed by deletion of a second gene, SML1.

Thus, in a strain that is already sml1-minus, MEC1 would appear to be non-essential.

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S L Forsburg, PhD  Associate Professor
Molecular Biology and Virology Lab
The Salk Institute, La Jolla CA

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