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postdoc positions

Richard J.Maraia maraiar at mail.nih.gov
Sun Jan 28 12:37:53 EST 2001


POSTDOCTORAL FELLOW
Biochemistry and Genetics of Eukaryotic RNA Expression
National Institutes of Health, USA

Basic mechanisms of RNA production will be investigated, using a highly
conserved pathway of tRNA biogenesis as a paradigm of eukaryotic gene
expression.  This pathway includes transcription, RNA processing,
intranuclear trafficking of RNA-protein complexes, and signal
transduction.  A multidisciplinary approach, involving genetics,
molecular biology and biochemistry, and a novel reporter system in
fission yeast, will be used.  Background in molecular biology and
biochemistry is essential.

Selected publications:
1) Maraia, R. J. and Intine, R. V. (2001) Recognition of nascent RNA by
the human La antigen: Conserved and diverged features of structure and
function. Mol Cell Biol, 21:367-379.

2) Intine RV, Sakulich AL, Koduru SB, Huang Y, Pierstorff E, Goodier JL,
Phan L, Maraia RJ., (2000) Control of transfer RNA maturation by
phosphorylation of the human La antigen on serine 366. Mol Cell,
6:339-348.

3) Huang Y, Hamada M, Maraia RJ. ( 2000) Isolation and cloning of four
subunits of a fission yeast TFIIIC complex that includes an ortholog of
the human regulatory protein TFIIIC-beta. J Biol Chem. Oct
6;275(40):31480-7.

4) Hamada M, Sakulich AL, Koduru SB, Maraia RJ. ( 2000) Transcription
termination by RNA polymerase III in fission yeast. A genetic and
biochemically tractable model system. J Biol Chem. Sep
15;275(37):29076-81.

5) Fan H, Sakulich AL, Goodier JL, Zhang X, Qin J, Maraia RJ. (1997)
Phosphorylation of the human La antigen on serine 366 can regulate
recycling of RNA polymerase III transcription complexes. Cell. Mar
7;88(5):707-15.

Also see:  http://eclipse.nichd.nih.gov/nichd/Maraia/Maraialabpage.html

It is important that your application includes a statement detailing
your specific scientific interest in this position, a C.V., and 3
references.  Send to: Richard J. Maraia, M.D., by E-mail:
maraiar at mail.nih.gov or post it to 6 Center Drive, MSC-2753, Bethesda,
MD, USA 20892-2753, or Fax to: 301 480-6863.

NIH is an equal opportunity employer



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