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Boston-Yeast Signal Transduction and Cancer Postdoc Position Avail

Athan Kuliopulos athan.kuliopulos at tufts.edu
Tue Aug 21 17:01:45 EST 2001

Postdoctoral Position Available
Division of Hematology-Oncology
Molecular Cardiology Research Institute
Tufts University School of Medicine-NEMC
Boston, MA

We have an immediate opening for a Postdoctoral Fellow to work on G
protein coupled receptor-dependent signal transduction.  The project
involves genetic and biochemical studies of the somatostatin receptors
expressed in yeast.  Heterologous expression of a somatostatin
receptor-G-protein pair will activate a defined signal transduction
pathway that leads to a distinct, unambiguous phenotype—growth.  The
high expression levels of somatostatin receptors (SSTR1-5) in malignant
tumour cells indicates a potential for somatostatin to suppress growth,
as well as allowing for therapeutic treatment with somatostatin
analogues such as octreoscan.

The somatostatin receptors couple with various efficiencies to specific
mammalian G proteins in yeast, however, the molecular basis for the
coupling specificity is unknown.  Genetic studies of receptor, G
proteins, ligand, and downstream regulators will greatly aid in
understanding how these receptors activate mammalian signaling pathways
including those that promote or inhibit cancer cell growth, motility,
and invasion.  Our yeast expression system of the receptors coupled to
the endogenous yeast MAP kinases may also provide a screening method for
novel anti-cancer agents.

Our laboratory is located within the Division of Hematology-Oncology and
Molecular Cardiology Research Institute, a modern, well-equipped
facility supported by several core units including automated DNA
sequencing, oligonucleotide and peptide synthesis, plasmid preparation,
fermentation, and flow cytometry.  Qualifications for this position are
a Ph.D. degree and US citizenship or permanent residency.  Candidates
with training in yeast genetics who would like to acquire expertise in
biochemistry in the context of cancer are especially encouraged to
apply.  Interested candidates should e-mail a description of their
research interests, a CV, and names of three references to:

Athan Kuliopulos, MD, PhD
Assistant Professor of Medicine and Biochemistry
Director, Hemostasis and Thrombosis Laboratory
Tufts-New England Medical Center, Box 8486
750 Washington Street
Boston, MA 02111


athan.kuliopulos at tufts.edu

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