Subject: Postdoctoral Position
From: Bruce Klein/Tom Sullivan
Date: 8 March 2000
Blastomyces dermatitidis and Histoplasma capsulatum are
ascomycetous fungi responsible for human and animal mycoses. They belong
to a group of dimorphic pathogenic fungi that grow as a mold in the
environment, sporulate and infect through the pulmonary route. Upon
inhalation the spores germinate to produce budding yeast-phase cells that
can cause lung infection and disseminated disease. The phase transition is
essential for pathogenicity and can be induced in the lab via temperature
shift.
A NIH-funded postdoctoral position is available immediately to address
regulation of virulence genes during the mycelial-to-yeast phase
transition. The project focuses on identification of transcriptional
regulatory mechanisms that control expression of a well-defined yeast-phase
specific virulence gene in B. dermatitidis and related fungi (J Biol Chem
275; 7925, 2000. J Exp Med 189; 1207, 1999. J Biol Chem 270:30725, 1995.
J Immunol 154:753, 1995).
Candidates should have background and experience in molecular
biology and relevant techniques. Direct resume and inquiries to: Bruce
Klein, University of Wisconsin-Madison, 600 Highland Avenue, K4/434,
Madison, WI, 53792. FAX:608-263-0440. email: bsklein at facstaff.wisc.edu.
Phone: 608-263-9217.
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