POST-DOCTORAL RESEARCH IN TRANSCRIPTIONAL SILENCING BY YEAST
HETEROCHROMATIN
Post-doctoral positions are available immediately to study
transcriptional silencing in the budding yeast Saccharomyces
cerevisiae. Our laboratory is taking a combined genetic and biochemical
approach to understand the structure and dynamics of the silent
mating-type loci. Particular emphasis is directed towards understanding
how transcriptional silencing is established, maintained, and ultimately
propagated from one generation to the next. To this end, we are
developing a host of novel approaches to address the following issues:
1) the role of DNA replication in establishing silent chromatin; 2) the
role of cis-acting regulatory elements (silencers) in maintaining the
repressive structure; 3) the relationship between nuclear localization
and transcriptional repression; 4) the composition and structure of
biochemically isolated silent chromatin fragments. Significant progress
has been made on a number of these fronts (see Cheng and Gartenberg
2000, Genes Dev 14, 452-463; Ansari and Gartenberg 1999, PNAS 96,
343-348; Cheng, et al. 1998, PNAS 95, 5521-5526; Ansari and Gartenberg
1997, MCB 17, 7061-7068; Mirabella and Gartenberg 1997, EMBO 16,
523-533).
Highly motivated individuals with experience in yeast molecular
genetics, biochemistry, and/or general chromatin research are sought for
these positions. If interested, please contact me at the address below.
Marc R. Gartenberg, Ph.D.
Department of Pharmacology
UMDNJ/Robert Wood Johnson Medical School
675 Hoes Lane
Piscataway, NJ 08854-5635
phone: 732/235-5800
fax: 732/235-4073
e-mail: gartenbe at umdnj.edu
Robert Wood Johnson Medical School is on the campus of Rutgers
University and is part of a thriving scientific research community.
Adjacent to the medical school is the Center for Advanced Biotechnology
and Medicine (CABM). In addition, both The Waksman Institute of
Microbiology and The Cancer Institute of New Jersey (CINJ) are nearby.
There are over a dozen active yeast labs on campus that gather regularly
for joint meetings. Piscataway is located across the Raritan River from
New Brunswick, a recently revived small northeastern city. New York
City is a short 45 minute train ride to the north, the Atlantic Ocean
and beaches are 45 minutes to the east and the rolling hills of the
Garden State lie immediately to the west.
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