POSTDOCTORAL FELLOWSHIP National Institutes of Health, USA
RNA Synthesis and Processing / Biochemistry and Molecular Genetics
RNA expression in eukaryotes will be investigated using biochemical and
genetic analyses. Studies will include the interface of transcription by
RNA polymerase III and post-transcriptional processing. The goal is to
understand the mechanisms involved in these processes and their
regulation and impact on normal and pathological states of
proliferation. Human La antigen and pol III transcription factors (TFs)
are focal points of interest. Some studies include the expression of
Alu retroposons and associated factors.
Current studies make use of a novel system in fission yeast that was
designed to examine pol III termination and the role of La in tRNA
production. A tRNA opal suppressor of ade6-704 (and accumulation of red
pigment), is employed. This allows us to follow functional aspects of
tRNA expression pathways in vivo. Exciting new advances using this
system show that cellular tRNA levels can be controlled via
phosphorylation of La. We are now developing approaches to identify and
isolate the pathways and factors involved. The recent cloning of
several S. pombe TFIIIB, TFIIIC and polymerase III subunits has
accelerated our progress.
Queries should include a statement of your interest in this position
and previous experience, C.V., names and email addresses and phone
numbers of three references. Send to R. J. Maraia, M.D., Chief, Section
on Molecular and Cell Biology, LMGR. E-mail: maraiar at mail.nih.gov.
FAX: 301 480-6863. Postal address: MSC-2753 9000 Rockville Pike,
Bethesda, MD 20892.
Richard J. Maraia, M.D.
Head, Section on Molecular and Cell Biology
Laboratory of Molecular Growth Regulation
National Institutes of Health
Phone 301 402-3567
Fax: 301 480-6863
Email: maraiar at mail.nih.gov
URL: http://eclipse.nichd.nih.gov/nichd/Maraia/Maraialabpage.html
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