A post-doctoral position will become open in my lab
early this summer. Several exciting project possibilities are available,
all using yeast as a model system to study genes/ proteins associated with
human genetic
disease. We have two projects currently funded and with openings, one
relating to studies
of proteins/ pathways relevant to galactose metabolism and galactosemia,
the other relevant
to studies of KH-domain RNA-binding proteins in yeast (related to the
Fragile X syndrome-
associated protein FMRP). Some relevant references are listed below.
Prior molecular
experience is required, and prior experience with yeast is preferred (but
not required).
Applicants should please send a CV and list of three references (with
contact information) to
Judith L.
Fridovich-Keil, Ph.D., Assoc. Professor
Emory
University School of Medicine
Department of
Genetics
Rm. 431C
Dental Bldg., 1462 Clifton Rd, NE
Atlanta, GA 30322
Phone:
404-727-3924
Fax: 404-727-3949
jfridov at emory.edu
Some relevant references:
Elsevier, J.P. and J.L. Fridovich-Keil. (1996) The Q188R mutation in human
galactose-1-phosphate
uridylyltransferase acts as a partial dominant negative. J. Biol. Chem.
271:32002-32007.
Quimby, B.B., A. Alano, S. Almashanu, A.M.. DeSandro, T.M. Cowan, and J.L
Fridovich-Keil. (1997)
Characterization of two mutations associated with epimerase-deficiency
galactosemia using a yeast
expression system for human UDP-galactose-4-epimerase. Am. J. Hum. Gen.
61:590-598.
Wohlers, T.M., N.C. Christacos, M. T. Harreman, and J.L. Fridovich-Keil.
(1999) Identification and
characterization of a mutation in the human UDP-galactose-4-epimerase
(GALE) gene associated with
generalized epimerase-deficiency galactosemia. Am. J. Hum. Gen. 64:462-470.
Lang, B.D and J.L. Fridovich-Keil. (2000) Scp160p, a multiple KH-domain
protein, is a component of
mRNP complexes in yeast. Nucleic Acids Res. 28:1576-1584.
Judith L. Fridovich-Keil, Ph.D.
Emory University School of Medicine
Associate Professor
Department of Genetics
Rm. 431C Dental Bldg
1462 Clifton Road, NE
Atlanta, GA 30322
TEL 404-727-3924
FAX 404-727-3949
email jfridov at emory.edu
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