A postdoctoral position is available to study protein trafficking and
quality control in the secretory pathway in the yeast Saccharomyces
cerevisiae. We study trafficking of the essential plasma membrane
transporter, Pma1. We have taken advantage of several
temperature-sensitive pma1 mutants that are defective in localization of
newly synthesized ATPase to the plasma membrane. Genetic screens to isolate
suppressors of these targeting-defective mutants has led to the
identification of many new genes that prevent mislocalization of Pma1 by
changing membrane traffic and/or affecting quality control. See J. Cell
Biol. (1997) 138: 731-746; EMBO J. (1999) 18: 5972-5982; Mol. Biol Cell
(2000) 11: 579-592. Applicants should have a background in molecular
biology, genetics or cell biology. Salary based on experience. Submit
curriculum vitae and three references to: Dr. Amy Chang, Department of
Anatomy/Structural Biology, Albert Einstein College of Medicine, 1300
Morris Park Ave., Bronx, N.Y. 10461. Email: achang at aecom.yu.edu.
Assistant Professor
Department of Anatomy & Structural Biology
Albert Einstein College of Medicine
1300 Morris Park Ave.
Bronx, New York 10461
Tel: (718)430-2739
FAX: (718)430-8996
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