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Stevan Marcus stevan_marcus at molgen.mdacc.tmc.edu
Fri Mar 12 18:21:10 EST 1999

AVAILABLE POSTDOCTORAL POSITION to study cellular signaling and growth regulatory pathways mediated by Ras and Ras-related (i.e., Cdc42, Rac, and Rho) small G proteins. Currently, our studies focus on three main areas:

(1)	Characterization of the function and regulation of p21-activated protein kinases (PAKs).
(2)	Regulation of cell cycle progression by Cdc42/PAK signaling pathways.
(3)	Regulation of MAP kinase signaling cascades.

Applicants should have experience in recombinant DNA methodologies, molecular biology and cloning, and protein biochemistry (SDS-PAGE and Western blotting). If interested, please send your CV and the names of 3 references to:

Stevan Marcus, Ph.D.
UT M.D. Anderson Cancer Center
Department of Molecular Genetics
1515 Holcombe Blvd.
Houston, TX 77030
ph. 713-745-2032
FAX 713-794-4394
e-mail smarcus at mdacc.tmc.edu

Selected Publications:
Polverino, A., J. Frost, P. Yang, A.M. Neiman, M. Hutchison, M.H. Cobb, and S. Marcus (1995) Activation of mitogen-activated protein kinase cascades by p21-activated protein kinases in cell-free extracts of Xenopus oocytes.  J. Biol. Chem. 270:26067-26070.

Frost, J.A., S. Xu, M.R. Hutchison, S. Marcus, and M.H. Cobb (1996) Actions of Rho family small G proteins and p21-activated protein kinases on extracellular-regulated protein kinases, c-Jun N-terminal kinase/stress-activated protein kinase, and p38 mitogen-activated protein kinases. Mol. Cell. Biol. 16:3707-3713.

Gilbreth, M., P. Yang, D. Wang, J. Frost, A. Polverino, M.H. Cobb, and S. Marcus (1996) The highly conserved skb1 gene encodes a protein that interacts with Shk1, a fission yeast Ste20/PAK homolog. Proc. Natl. Acad. Sci., USA, 93:13802-13807.

Yang, P., S. Kansra, R. Pimental, M. Gilbreth, and S. Marcus (1998) Cloning and characterization of shk2, a gene encoding a novel p21-activated protein kinase from fission yeast. J. Biol. Chem., 273:18481-18489.

Gilbreth, M., P. Yang, G. Bartholomeusz, R. Pimental, S. Kansra, R. Gadiraju, and S. Marcus (1998) Negative regulation of mitosis in fission yeast by the Shk1-interacting protein Skb1 and its human homolog, Skb1Hs. Proc. Natl. Acad. Sci., USA, 95:14781-14786.

Stevan Marcus, Ph.D.

Dept. of Molecular Genetics
UT M.D. Anderson Cancer Center
1515 Holcombe Blvd.
Houston, TX 77030
713-794-4394 (FAX)
smarcus at mdacc.tmc.edu

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