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Post-doctoral position

Andrew J Brown AB43800 at Glaxowellcome.co.uk
Tue Dec 14 06:11:37 EST 1999


Title: The mating pheromones and receptors of the mushroom Coprinus
cinereus: a model system for studying G-protein-coupled receptors. 

Applications are invited for a 3-year BBSRC-funded postdoctoral position
in the Department of Plant Sciences, University of Oxford. Starting
salary £16,286-£18,185. The grant holders are Professor Lorna A.
Casselton of the University of Oxford and Dr Andrew Brown of
GlaxoWellcome. 

Project: Coprinus cinereus encodes a large family of mating pheromones
and G-protein-coupled receptors (GPCRs) that play a major role in mate
recognition. We have developed a heterologous assay to study receptor
activation in yeast (EMBO J. 18:2756-63) using both natural and
synthetic pheromones. We now wish to exploit the natural variability of
the Coprinus family to learn more about the biology of GPCRs. The
project will isolate new receptors and pheromones and use yeast to study
the specificity of their interactions. Also, receptors will be localised
within Coprinus hyphal cells by tagging.

Applications quoting ref. no PRA/36 and including curriculum vitae, a
list of principal publications and the names and contact details of two
referees should be sent to the Administrator, Department of Plant
Sciences, South Parks Road, Oxford OX1 3RB by the stated closing date of
24th January 2000.

Informal enquiries may be made to: 

Professor Lorna A. Casselton, e-mail: lorna.casselton at plants.ox.ac.uk
or, Dr Andrew Brown, email: ab43800 at GlaxoWellcome.co.uk
---





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