Our laboratory uses yeast to study how newly synthesized RNA molecules
are folded, processed, and assembled with proteins. A major focus is
the role of the La protein, an abundant phosphoprotein that is the first
protein to bind many newly synthesized small RNAs. Our work strongly
suggests that this protein functions as a molecular chaperone to
facilitate the correct fate of these RNAs (see Pannone et al., EMBO J.
17, 7442-7453; Yoo and Wolin, Cell 89, 393-402). Candidates should
possess a recent Ph.D. degree and have experience in yeast genetics,
biochemistry or molecular biology.
Send curriculum vitae, a brief summary of research experience and the
names of three references to Dr. Sandra L. Wolin, Departments of Cell
Biology and Molecular Biophysics and Biochemistry, Howard Hughes Medical
Institute, Yale University School of Medicine, 295 Congress Avenue, New
Haven, CT 06536