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Hansenula polymorpha problem

Shelley Ann des Etages shelley.desetages at yale.edu
Sun Jul 5 18:46:21 EST 1998


Hello Jonny,
                        Your strain MAY be undergoing "genome renewal".
Bob Mortimer et al. published a paper about this phenomenon in Yeast
10:1543-1552 ( 1994).  The genome renewal phenomenon occured in several
Saccharomyces strains that they had isolated from fermenting grape
musts.  These diploid strains changed from  being heterozygous at
multiple loci to complete homozygotes.  Perhaps there is a similar thing
occuring in your strain.  Is the strain hapolid or diploid, how well
characterized is it?  Maybe they sent you the wrong strain?   Good luck!

Shelley
sgd4 at pantheon.yale.edu





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