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Postdoctoral position available

Seth J. Orlow orlows01 at MCRCR6.MED.NYU.EDU
Sat Jan 24 11:37:06 EST 1998

Dear colleagues:

A three-year postdoctoral position is available immediately, funded by
research grants from the NIH and the Anaderm Research Corporation/Pfizer.
The successful candidate will join a research group studying
the biogenesis of the melanosome, the endolysosomally-related organelle in
which melanin is synthesized and deposited within the vertebrate eye and
skin. We are employing S. cerevisiae not only for use in the two-hybrid
system, in order to examine the interaction between melanosomal proteins
and other proteins including yeast and mammalian adaptor protein subunits,
but also are expressing melanosomal membrane proteins heterologously in
wild type and mutant yeast strains to study their trafficking and to
determine if they can suppress or cause synthetic lethality with known
yeast mutations in order to gain insight into their functions. This
approach combines the power of yeast and mouse coat color genetics to
address the function of mammalian gene products in which mutations cause
oculocutaneous albinism and in some cases multisystemic disorders. Our
laboratory is located within the Department of Cell Biology at the New York
University Medical Center in New York.

Applicants should have a Ph.D., with experience in yeast genetics and
molecular biology. Expertise with protein subcellular localization
(immunofluorescence and/or biochemical fractionation) would be considered
an advantage, but is by no means essential. Salary rate is negotiable and
will be set according to experience. The position may be extended for an
additional two years, depending on the availability of funds.

If interested, please send a letter describing your research interest, a CV,
and the names and e-mail address/phone numbers of three references to:
Dr. Seth J. Orlow
NYU School of Medicine
560 First Avenue, Room H-100
New York, NY 10016 USA
212-263-5070 lab
212-263-5819 fax
email: orlows01 at mcrcr.med.nyu.edu

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