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post-doc position, cell cycle

Nancy Walworth walworna at UMDNJ.EDU
Tue Oct 28 17:40:19 EST 1997


A post-doctoral position is available immediately to study the effect of 
DNA damage on cell cycle regulation in the fission yeast, S. pombe.  
Projects are directed toward elucidation of the signal transduction 
pathway that couples the detection of DNA damage to control of cell cycle 
progression.  These studies revolve around characterization of the chk1 
encoded protein kinase which is required for cell cycle arrest when DNA 
damage takes place (see Walworth et al., 1993, Nature 363:368-371).  The 
chk1 protein kinase is phosphorylated in response to DNA damage and this 
event is dependent on the activity of many of the checkpoint rad gene 
products, including rad3, a homologue of the human ATM gene (see Walworth 
and Bernards, 1996, Science 271:353-356).  ATM is defective in 
individuals with the recessive genetic disorder Ataxia Telangiectasia and 
is thought to increase the risk of cancer in heterozygous individuals.  
Recent developments suggest that a human homologue of chk1 exists and 
that it responds to DNA damage in the same way as S. pombe chk1 
(see the September 5, 1997 issue of Science).  Elucidation of the 
chk1-dependent DNA damage checkpoint pathway is essential to 
understanding how cells cope with DNA damage and avoid becoming cancer 
cells.  Our laboratory is taking a combined genetic and biochemical 
approach to dissect how a DNA damage signal is communicated to the cell 
cycle control machinery.

If you are interested in participating in this line of research, please 
contact me at the address below.  Experience with yeast genetics or 
biochemistry is a plus!

Dr. Nancy Walworth 			email:	walworna at umdnj.edu
Department of Pharmacology
UMDNJ/Robert Wood Johnson Medical School
675 Hoes Lane
Piscataway, NJ  08854-5635

phone:	(732) 235 5661
fax:	(732) 235 4073

UMDNJ-RWJohnson Medical School is on the campus of Rutgers University and 
is part of a thriving and growing scientific research community.  
Adjacent to the medical school is the Center for Advanced Biotechnology 
and Medicine which houses both Medical School and Rutgers faculty.  In 
addition, both The Waksman Institute of Microbiology and The Cancer 
Institute of New Jersey are nearby.  There are over a dozen active yeast 
labs on campus that gather regularly for joint meetings.  Piscataway is 
located across the Raritan River from New Brunswick, a recently revived 
small northeastern city.  New York City is a short 45 minute train ride 
to the north, the Atlantic Ocean and beaches are 45 minutes to the east 
and the rolling hills of the Garden State lie immediately to the west.

Nancy Walworth, Ph.D.                      tel:	732 235 5661
Assistant Professor			   fax:	732 235 4073
Dept. of Pharmacology
UMDNJ/Robert Wood Johnson Medical School   email:  walworna at umdnj.edu
675 Hoes Lane
Piscataway, NJ 08854-5635

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