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postdoctoral position-yeast

Steve Hanes steven.hanes at WADSWORTH.ORG
Wed Jun 11 20:58:58 EST 1997

Postdoctoral Position 
Yeast Genetics

NIH-funded position available July 1 to study the ESS1 gene that is
conserved in yeast, flies and humans and encodes a novel
prolyl-isomerase required for mitosis (PNAS 93:447, 1996; Nature
380:544, 1996).  ESS1 likely functions in a mitotic control pathway
distinct from that of p34cdc2/28.  The Ess1 protein and its homologs are
the only known proteins to contain both a WW domain and a PPIase
(peptidyl-prolyl isomerase) domain.  The WW domain is a protein-protein
interaction module found in proteins such as Dystrophin, encoded by the
human muscular dystrophy gene.  The PPIase domain is a catalytic module
that controls the folding and activity of kinases, receptors and
transcription factors and is found in proteins like cyclophilin that
mediate the effects of immunosuppressive drugs.  The candidate will use
yeast genetics and cell biology to investigate how Ess1 controls mitotic
progression and how the WW and PPIase domains contribute to this
activity.  Projects might include characterization of cell cycle
phenotypes of ts-mutants, characterization of Ess1-interacting proteins,
isolation of second-site suppressors, and genetic dissection of the ESS1

Candidate must have experience with yeast genetics and/or cell cycle
analysis.  Position is at the Wadsworth Center, a well-funded,
state-of-the-art facility of the New York State Department of Health and
Department of Biomedical Sciences, State University of New York-Albany. 
There is a large group of active researchers whose fields include
genetics, microbiology, cell biology, structural biology (X-ray, NMR),
virology etc. (see http://www.wadsworth.org/BMS/).  There are three
other yeast labs at the Wadsworth Center and monthly Albany Area Yeast
Meetings include at least 4 additional yeast/fungal groups.   

Albany is a pleasant, relatively inexpensive, small city located in
upstate New York, near the Adirondack Mountains, 3 hrs from Boston and
2.5 hrs from New York City.  

Send HARD COPY (please, no e-mail) of CV, statement of research
interests and list of three references to the following address:  

Steven Hanes, Ph.D. 
Wadsworth Center
120 New Scotland Avenue
Albany, NY 12208

Administered by Health Research, Inc., an affirmative action/equal
opportunity employer

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