The relationship between tRNA gene multiplicity and codon selection in
yeast, emerging from the analysis of the complete genome of
Saccharomyces cerevisiae, has been recently described in a paper*.
A program for calculate the correlation between codon frequency of a
Saccharomyces cerevisiae coding sequences and the gene copy number of
the relevant tRNAs is available at the WWW site:
Correlation coefficient and regression analysis values proved to be
effective descriptors of the translational selective pressure operating
on a particular gene suggesting their use to infer the expression level
of individual yeast protein coding sequences.
*Transfer rna gene redundancy and translational selection in
Saccharomyces cerevisiae. 1997 J.Mol.Biol 268 (2) 322-330
Institute of Biochemical Sciences
University of Parma, I-43100