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Donald Tipper dtipper at sunspot
Thu Apr 10 13:47:33 EST 1997


Donald Tipper, Dept of Mol. Genetics and Microbiol, U. Mass Med school.
Worcester, MA 01655.          Telephone, 508 856 2308.     FAX, 508 856 5920

A Post-Doctoral position is available from June 1 97, funded for three years.


          We are analyzing the determinants of transmembrane  (TM) Protein
Insertion Orientation (PIO) in yeast.  Initial results (JBC , 1996,  271
24625-33)  established the validity of the charge difference rule.  We 
are now
analyzing  charge-independent determinants and the attenuation of the charged
signal by distance.  A refined rule for topology prediction will be 
derived and
applied to the yeast proteome database.

         Mutants have been isolated in which PIO is relaxed.  We 
anticipate that
cloning will identify the components of the receptor responsible for 
determining
PIO, a primary event in protein translocation at the ER.


Donald Tipper
University of Massachusetts - Worcester Campus
Donald.Tipper at ummed.edu




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