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Lithium and Growth

* at sbsu1.auckland.ac.nz * at sbsu1.auckland.ac.nz
Sat Apr 5 13:10:07 EST 1997

In article <199704011652.LAA14359 at argus.acpub.duke.edu>,
nc1 at ACPUB.DUKE.EDU (Namjin Chung) wrote:

> Have been there any reports about correlation between lithium and yeast 
> cell proliferation?  Though I heard that lithium inhibits one of many 
> inositol phosphatases, I am not sure if it inhibit cell growth?

Hi N.,
The HAL2 gene encodes a phosphatase inhibted by Li ions, in fact this
enzyme catalyses a rate limiting step for growth in the absence of
methionine.  Hope this helps,

Colin MacDiarmid,
University of Auckland
macdiarm at sbsu1.auckland.ac.nz

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