Stuart Montgomery wrote:
>> Hi,
> I am a third year student at Imperial College London and as part of my
> degree I have to do a dissertation. The subject that I choose was CDKs
> and Cyclins. I intend to centre on the cell cycle for obvious reasons,
> but try to bring in other areas in which cyclins are involved that may
> not immediately be thought of as part of the cell cycle.
> At the moment I have:
> cell cycle,
> involvement in phosphate uptake in yeast,
> neurite outgrowth,
> transcription machinery cyclins,
> interaction with tyrosine kinase pathways e.g. growth factors,
> possible involvement in once per cell cycle DNA replication.
>> I would also like to look at structure and homologies of cdks and cyclins
> and the relevance to function.
>> Any help with good references, other areas of cyclin involvement or
> comments and ideas on why cyclins are involved in processes outside the
> cell cycle would be greatly appreciated.
>> Thanks
> Stuart
>> ################################################################
> # Stuart Montgomery Home Phone No.+44 (0)171 252 5754 #
> # #
> # Biochemistry Dept. #
> # Imperial College #
> # Exhibition Road E-mail= s.montgomery at ic.ac.uk #
> # London SW7 2AY sm4 at bccmsa.bc.ic.ac.uk #
> ################################################################
Stuart,
It appears to me that your thesis adviser (or potential thesis adviser) would be the best
person to provide the direction of your thesis and his/her perpectives of CDKs and cyclins are
most important as far as your thesis is concern. If you he/she is not familiar with the field, I
hope you have an option to choose another adviser. Intellectually, your questions are
interesting. Practically, what counts is what your advisor considers "hot". If you concentrate in
the areas where your advisor is pointing, your efforts still count for something even the
experiments don't work out. If you go independent and things don't work out, I think it's going
to be a lot of work getting back to square one. Just my two cents.
In my old file (when I took courses) I found,
P. Norbury and P. Nurse "Animal cell cycles and their control" Annu. Rev. Biochem, 1992,
61:441-70.
F. Cross et. al "Simple and complex cell cycles" Annu. Rev. Cell Biol., 1989, 5:341-95.
A review by J. Kurjan in Annu. Rev. Biochem. about Pheromone signal transduction pathway. The
second half of the review connects STE12 and the downstream elements (mostly cyclins). I can't
find the reference, but it was written in the 90's.
By the way, if you find hints of connection between cyclins and cell wall
biosynthesis/degradation, drop me a note.
Sincerely,
Chong
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Chong K. Jue
Dept. of Biological Sciences
695 Park Ave
NY NY 10021
eMail: lipke at genectr.hunter.cuny.edu
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