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tunicamycin and yeast growth

killer yeast vvsvetlov at utmem1.utmem.edu
Thu Jun 13 20:52:43 EST 1996

In article
<Pine.A32.3.91.960611131020.26911A-100000 at dekan.phoenix.yorku.ca>, Lew
Roger <planters at dekan.phoenix.yorku.ca> wrote:

>         Has anyone worked on this? I would be very interested in how large
> the cells become. Alternatively, could someone point me in the direction
> of any references to this effect of tunicamycin? 

As far as I can remember tunicamycin blocks post-translational protein
glycosylation causing aberrant presumptive glycoproteins to accumulate in
ER. This state has some feautures of classic heat-shock response due to
accumulation of malfolded polypeptides. The papers I remember reading did
not emphasize enlargement of the cells but rather transcriptional effects.
If you want some refs check for KAR2 papers first.
V. Svetlov

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