On Thu, 05 Dec 1996 16:56:20 -0400,
Van Wuytswinkel Olivier <vanwuyts at chem.vu.nl> wrote:
>Hi everybody !
>>Well, I have got a little problem to find a company that sells the FK506
>calcineurin inhibitor. I want to use it on yeast cells. I know that this
>chemical is also used in medecine in connection with organ
>transplantation. So I guess that I could find a pharmaceutical company
>that produce FK506 to order it, but no way.
>Does anybody can help me?
>>Maybe do you know the name of another chemical that inhibits calcineurin
>and that can be easily ordered.
>>Thank you for your help.
Another organ transplantation agent, cyclosporin A (CsA), inhibits
calcineurin in the same fashion as does FK506 (Liu, J., et. al.
1991. Calcineurin is a common target of cyclophilin-cyclosporin A
and FKBP-FK506 complexes. Cell 66, 807-815) Sandoz makes CsA, so you
should start with them. Or you could try bugging research labs who
work with either FK or CsA.
Ed Davis, Ph.D., B.A., M.Phil, H.S., K.9., *.69., D.dt., M.Sg.
ABL-Basic Research Program
P.O Box B
Frederick, MD 21702-1201
e-mail: davise at ncifcrf.gov