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Toxic galactose analogs?

Eckhard Boles boles at bio1.bio.th-darmstadt.de
Mon Nov 27 03:35:47 EST 1995


Dear Arle,

nice to hear from you.
I found an article about 2-deoxygalactose inhibition of glycolysis.
Best regards

Eckhard

Dr. Eckhard Boles
TH Darmstadt
Germany
Email: boles at bio1.bio.th-darmstadt.de


 Author	R Lagunas, E Moreno
 Title	Inhibition of Glycolysis by 2-Deoxygalactose in 
	Saccharomyces cerevisiae
 Source	Yeast 8: 2 (FEB 1992)
 Page(s)	107-115
 Abstract  The enzymatic steps involved in the inhibition of glycolysis 
by 2-deoxygalactose in Saccharomyces 
cerevisiae have been investigated. Yeast, incubated with 
2-deoxygalactose, accumulates up to 8 mM-
2deoxygalactose, 30 mM-2-deoxyplactose-1-phosphate and 0.25 
mM-UDP-2-deoxygalactose and UDP-
2deoxyglucose. An inverse correlation between 2deoxyplactose-1-phosphate 
content and rate of glycolysis has 
been observed. The intracellular concentration of glycolytic 
intermediates and related metabolites point to the 
hexokinase and phosphofructokinase steps as the targets for the 
inhibition of glycolysis by 2-deoxygalactose and rule out all other 
mechanisms that have been proposed to 
explain this inhibition.






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