nice to hear from you.
I found an article about 2-deoxygalactose inhibition of glycolysis.
Dr. Eckhard Boles
Email: boles at bio1.bio.th-darmstadt.de
Author R Lagunas, E Moreno
Title Inhibition of Glycolysis by 2-Deoxygalactose in
Source Yeast 8: 2 (FEB 1992)
Abstract The enzymatic steps involved in the inhibition of glycolysis
by 2-deoxygalactose in Saccharomyces
cerevisiae have been investigated. Yeast, incubated with
2-deoxygalactose, accumulates up to 8 mM-
2deoxygalactose, 30 mM-2-deoxyplactose-1-phosphate and 0.25
mM-UDP-2-deoxygalactose and UDP-
2deoxyglucose. An inverse correlation between 2deoxyplactose-1-phosphate
content and rate of glycolysis has
been observed. The intracellular concentration of glycolytic
intermediates and related metabolites point to the
hexokinase and phosphofructokinase steps as the targets for the
inhibition of glycolysis by 2-deoxygalactose and rule out all other
mechanisms that have been proposed to
explain this inhibition.