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Signal Transduction Postdoc Avail/Boston

Fri Feb 3 10:21:14 EST 1995

Postdoctoral Position Available
Tufts University School of Medicine-NEMC
Boston, MA

We have an immediate opening for a Postdoctoral Fellow to 
work in the field of molecular signaling and peptide-protein 
recognition.  The project focuses on the yeast mating 
peptide-receptor and the human thrombin receptor.  These 
receptors activate signal transduction pathways culminating 
in cell cycle mitotic arrest in the case of the yeast system 
and platelet aggregation in the case of the thrombin 
receptor.  Molecular biology techniques will be used to 
construct recombinant receptors and express these receptors 
in yeast strains.  Receptors will be characterized by 
various genetic and physical methods, purified, and labeled 
with affinity-peptides.  Insight into the molecular 
interactions between these peptides and their cognate 
receptors should provide leads for the development of anti-
thrombotic agents.  The laboratory is located within the 
Center of Hemostasis and Thrombosis Research, a modern, 
state-of-the-art facility with a staff of 20 investigators 
including technical support.  Funds for this position derive 
from an NIH Training Grant in Hematology from the National 
Heart Lung and Blood Institute.  Qualifications for this 
position are a Ph.D. degree and US citizenship or permanent 
residency.  Candidates with training in yeast genetics who 
would like to acquire expertise in protein chemistry are 
encouraged to apply.  Interested candidates should send a 
letter describing their research interests, a CV, and names 
of three references to:

Athan Kuliopulos, MD., Ph.D.
Departments of Medicine and Biochemistry
Tufts-NEMC Box 832
750 Washington Street
Boston, MA 02111

617-636-4833 (fax)
akuliopu at opal.tufts.edu

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