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THE PRELIMINARY ANNOUNCEMENT
NATO Advanced Study Institute on
MOLECULAR AND APPLIED ASPECTS OF OXIDATIVE DRUG METABOLIZING ENZYMES
August 31-September 11, 1997
OBJECTIVE AND SCOPE:
The purpose of the Institute is to provide an international forum for
dissemination of advanced scientific knowledge on molecular and applied
aspects of oxidative drug metabolizing enzymes, significance of these
enzymes in human drug metabolism, genotoxicology, chemical carcinogenesis,
insecticide resistance and drug development.
The Meeting will take place in a five star Hotel and Holiday village,
CORINTHIA in Tekirova, ANTALYA-TURKEY on the Mediterranean Coast. This
area is called as Turkish Riviera which possesses one of the finest
settings of Mediterranean. It is also littered with ancient ruins.
The city, Antalya has an International Airport which is readily accessible
by flights from Europe, Israel, as well as Istanbul, Ankara and Izmir.
SCIENTIFIC ORGANIZING COMMITTEE:
Emel ARINC (Turkey), Alan R. Boobis (UK)
Ernest Hodgson (USA) John B. Schenkman (USA)
Emel ARINC (Turkey) Steven L. KELLY (UK)
Alan R. Boobis (UK) Anthony Y.H. Lu (USA)
David EATON (USA) Franz OESCH (Germany)
Frank J. GONZALEZ (USA) Richard M. PHILPOT (USA)
Israel HANUKOGLU (Israel) John B. SCHENKMAN (USA)
Ernest HODGSON (USA) Volker ULLRICH (Germany)
Note: This is a preliminary announcement. ASI will have
3 or 4 more lecturer
ORGANIZATION and PROGRAMME
The lectures will usually be between 9:00 and 12:30 in the mornings and
16:00 and 19:30 in the afternoons with brief breaks for coffee or tea.
This schedule allows sufficient time for the scientific sessions and other
activities. The morning sessions will be devoted to lectures only. The
late afternoon sessions will also include discussion, poster sessions and
a limited number of paper presentations.
The following lectures will be given:
-Drug Metabolizing Enzymes: An overview (J. B. Schenkman)
-Molecular Biology of Cytochrome P450: P450 Genes, Their Expression and
Regulation (F. J. Gonzalez)
-Chemical Principles of Heme Thiolate Catalysis (V. Ullrich)
-Other Components of P450 Dependent System (E. Arinc)
-Mitochondrial P450 System: Function and Components and Structures (I.
-Protein-Protein Interactions in the Multicomponent Monooxygenase
Reactions (J. B. Schenkman)
-Biochemical Aspects of FMOs (E. Hodgson)
-Molecular Aspects of FMOs (R. M. Philpot)
-Molecular Basis of Chemical Carcinogenesis (F. J. Gonzalez)
-Human Cytochromes P450 (A. R. Boobis)
-Human Cytochromes P450 Polymorphism: Role in Cancer Susceptibility (F.
-In Vitro Studies of Human P450 Enzymes (A. R. Boobis)
-Aflatoxin Biotransformations, Toxicity and Carcinogenicity (D. Eaton)
-The Biochemistry and Physiology of Prostacyclin and Thromboxane
Synthase (V. Ullrich)
-Insect P450 Isozymes, Functions and P450-Mediated Insecticide
Resistance (E. Hodgson)
-Drug-Drug, Drug-Xenobiotic Interactions (F. Oesch)
-Biotechnological Applications of Cytochrome P450 Isozymes (S. L. Kelly)
-Drug Metabolism Studies in Drug Discovery and Development (A.H.Y. Lu)
Lecture notes written in a review type will be published shortly after the
Meeting by PLENUM Press and one copy will be distributed to each
participants and lecturer free of charge.
Advanced Study Institute will accomodate about 85 graduate students,
post-doctoral fellows, senior scientist from universities, governmental
organizations and the industry. Full attendance to the Institute is
Participants are expected to cover their own travel and living expenses.
Partial support is available. The total cost of ASI including abstract
book, full-board, coffee servings, all you can drink (Turkish alcoholic
beverages), whole day snacks, sauna and Turkish bath and some other
activities is 770 US dollars per person sharing a double room. Accomodations
for the participants' family members are available at the same cost as for
the participants. Children at 0-6 years will be free of charge. Children
7-12 years old 35 US dollars per night staying with the parents.
EXHIBITS and MANUFACTURER'S FORUM:
A limited amount of space is available for exhibiting. If you are
interested in exhibiting or advertising in the Conference Documentation or
sponsoring the Manufacturer's Forum, contact to Dr. E. Arinc.
FOR FURTHER INFORMATION AND APPLICATION FORMS
Contact: Dr. Emel ARINC
Middle East Technical University, ODTU
E-mail:earinc at metu.edu.tr