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NIEHS: Grant: Studies Of Chemical Disposition In Mammals

Gary Greenberg Gary.Greenberg at Duke.edu
Sat Jun 23 08:49:13 EST 2001


STUDIES OF CHEMICAL DISPOSITION IN MAMMALS

http://grants.nih.gov/grants/guide/notice-files/NOT-ES-01-008.html

Release Date:  June 21, 2001

NOTICE:  NOT-ES-01-008

RFP NIH-ES-01-09

National Institute of Environmental Health Sciences

The purpose of this project is to obtain detailed chemical disposition
data from 3 to 6 studies per year of selected environmental
contaminants or model compounds per year.

The purpose of this contract is to procure detailed chemical
disposition data from a number of selected environmental contaminants
or model compounds per year. Most of these studies will be conducted
in Fischer 344 rats and/or B6C3F1 mice. There are infrequent occasions
where other strains of rats (e.g. Sprague-Dawley) or mice (e.g.
Swiss-Webster) will be required to meet the needs of the NTP.  Rarely,
other laboratory rodent species such as hamsters will be required. 
(Note: For costing purposes, offerors should assume that all studies
will be conducted in Fischer 344 rats and/or B6C3F1 mice.) Most
studies will address the disposition of organic chemicals; however,
studies of inorganic chemicals may also be requested. Individual
studies may vary in complexity from preliminary investigations of
chemical absorption to detailed studies of all phases of chemical
disposition, toxicokinetics, and metabolism.  The immediate goal of
these studies is to provide data to be used in determination of dose,
route of administration, and interpretation of NTP bioassay studies.
The long-range goal is the accumulation of data that will permit a
better assessment of structure-activity relationships for chemical
absorption, metabolism, and disposition in laboratory animals and to
better interpret the significance of these data to humans.  This
project will cover a five year period with two awards.  This project
will cover a five year period with two awards.  The government
estimates that the project will require approximately 2.0 professional
person-years and 3.0 technical person years per contract year.
Requests must reference RFP No. NIH-ES-01-09 and must be directed to
the office listed below.  Release of the RFP is anticipated on or
about July 13, 2001 with proposals due August 14, 2001.  All
responsible sources may submit a proposal which shall be considered by
the Agency.


Requests should be forwarded to:

National Institute of Environmental Health Sciences
Research Contracts Branch, DERT
ATTN:  Howard Hill, Contract Specialist
79 T.W. Alexander Drive, Building 4401 Research Commons
P.O. Box 12874
Research Triangle Park, NC  27709
(919) 541-4971 (Telephone)
(919) 541-2712 (Fax)
hill6 at niehs.nih.gov

-- 
Gary N. Greenberg, MD MPH    Sysop / Moderator Occ-Env-Med-L MailList
gary.greenberg at duke.edu     Duke Occupat, Environ, Int & Fam Medicine
OEM-L Maillist Website:                      http://occhealthnews.net

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