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Immune Reactive Conditions: Eczema, lupus, autism and Mercury

arie_ at hotmail.com arie_ at hotmail.com
Sun Mar 19 14:46:20 EST 2000


Subject:  SCI:  references for BW paper: mercury & eczema, lupus,
autism, etc.

Immune Reactive Conditions: Eczema, lupus, autism and Mercury -
snipped from a larger study
by B. Windham

So, with thanks to B. Windham:

The incidence of allergic and immune reactive conditions such as
allergies, asthma, eczema,lupus, oral lichen planus, autism, etc. have
been increasing rapidly in recent years (1, 2, 3).  The largest
increase has been in infants (1, 2, 6, 7), with an increase in autism
cases of over 250% to a level of almost 1 per 300 infants in the last
decade (2), and over 10 % of infants- approximately 15 million in the
U.S. with systemic eczema (1).  Studies researching the reason for
these rapid increases in infant reactive conditions seem to implicate
earlier and higher usage of vaccines containing mercury(thimerosal) as
a possible  connection (2b). Many thousands of parents have reported
that their child got such conditions after vaccination. 
Thimerosal had been previously removed from similar preservative uses
in eye drops and eye medications after evidence of a connection to
chronic degenerative eye conditions. The effect on the immune system
of exposure to various toxic substances such as toxic metals and
environmental pollutants has also been found to have additive or
synergistic effects and to be a factor in increasing eczema,
allergies, asthma, and sensitivity to other lesser allergens. Other
than the toxic metals which are discussed later, three such that have
been documented are traffic and industrial pollutants nitrogen oxide,
power plant residual oil fly ash, and organochlorine pollutants (4).

Allergic contact eczema is the most frequent occupational disease (1),
and the most common cause of contact eczema is exposure to toxic
metals (1, 5-9).  The metals most commonly causing allergic immune
reactivity are nickel, mercury, chromium, cobalt, and palladium (1,
5-12). The highest level of sensitization is to Infants, who are most
reactive to thimerosal, a form of mercury that has been used as a
preservative in vaccines and eye drops (6, 7). There is suggestive and
clinical evidence for a connection between toxic metals and autism
(21, 2b).

Although nickel has historically been the number one source of metal
allergy and contact allergy, with many dozens of medical studies
documenting the connection to conditions such as contact eczema, in
recent years the largest increase in infant reactivity appears to be
related to mercury exposure (6, 7, etc.). Thus in assessing mechanisms
by which these conditions are related to metals, this paper will focus
on mercury. Some of this would be similar for other metals however.

Medical studies looking for mechanisms by which mercury causes some of
these conditions found interferon syntheses was reduced in a
concentration dependent manner with either mercury or methyl mercury,
as well as other immune functions (13-15), and low doses also induce
aggregation of cell surface proteins and dramatic tyrosine
phosporlation of cellular proteins related to asthma, allergic
diseases such as eczema and lupus, and autoimmunity (14, 15). One
study found that insertion of amalgam fillings or nickel dental
materials causes a suppression of the number of T-lymphocytes (16),
and impairs the T-4/T-8 ratio.  Low T4/T8 ratio has been found to be a
factor in lupus, anemia, MS, eczema, inflammatory bowel disease, and
glomerulonephritis.
Many studies have found that the body's basic building blocks, amino
acids with SH hydroxyl radicals form strong bonds with the toxic
metals such as mercury, resulting in compounds which the immune system
recognizes as "foreign" or non-functional in the basic digestive
enzymatic processes that use them as fuel and building blocks in cell
structure.  This results in activation of the immune system, and when
there is a chronic exposure can lead to an autoimmune process that
results in significant  symptoms and various autoimmune diseases and
conditions such as these systemic allergic conditions as well as
others such as chronic fatigue (CFS), multiple chemical sensitivities
(MCS), and fibromyalgia (11-16, etc.).

As previously noted, many occupational and children's studies have
found mercury to be a common cause of immune reactivity and contact
and systemic skin conditions including eczema (4-12).  One of the
confusions about mercury is that there are several forms of mercury,
with different  mechanisms of exposure for the different forms, as
well as different mechanisms in which the forms of mercury affect the
body and immune system.  However all have been documented to be
extremely neurotoxic and immunotoxic, and to cause autoimmunity in
susceptible individuals.
And many studies as well as scientific panels have documented that the
number one source of mercury in most adults is amalgam fillings(16),
also that a mother's amalgam fillings through placental transfer and
breast milk are the main source of mercury in most infants, other than
from vaccinations (16).

Many studies including patch tests and immune reactivity tests have
been carried out to assess the level of mercury sensitivity in
different populations. They have found  that there is a significant
portion of the population that are reactive and sensitive to mercury
and such have significant effects. In a group of medical students
tested, 12.8 % were sensitive to mercury (17).  The mercury sensitized
students were found to have more than average number of amalgam
fillings, higher urine mercury than non-sensitized students, and more
allergic reactions to other things such as cosmetics, soaps, shampoos,
etc. Many other studies have found similar levels of sensitization in
recent years, with those populations with higher
exposures such as those with many fillings or dental staff tending to
have higher levels of sensitization (11, 12, 16) and more adverse
health effects. 
In a group of 8 with contact eczema patch tested for mercury in Spain,
all were positive for mercurochrome, six to inorganic mercury, and
some to thimerosal (18).  This study like several others noted the
danger in patch tests for mercury as 2 of the patients suffered
anaphylactic shock after the
patch test due to the extreme immune reactivity of some to mercury.
Inorganic mercury was found to be a cause of systemic eczema and
digestive problems by a  Japanese study (19).  There is consensus
among researchers and dental authorities that amalgam fillings is the
main cause of oral lichen planus and the condition is usually cured by
amalgam removal (86, 87, 90, 101, 168).

Many clinics and studies have found that patients with allergic
reactive conditions such as oral lichen planus, eczema, chronic
allergies etc. usually recover or have significant improvements after
amalgam replacement (11, 12, 16, 20, etc.).  Of a group of 86 patients
with CFS symptoms, 78% reported significant health improvements after
replacement of amalgam fillings within a relatively short period, and
MELISA test found significant reduction in lymphocyte reactivity
compared to pre removal tests (342, 368). 
The improvement in symptoms and lymphocyte reactivity imply that most
of the Hg-induced lymphocyte reactivity is allergenic in nature.
Patients with other systemic neurological or immune symptoms such as
arthritis, myalgia, CFS, MCS, MS, etc. also often recover after
amalgam replacement.
Cases of documented clinical cases with recovery after amalgam
replacement include:  eczema (60, 212, 222, 271, 313, 317, 323, 94,
376, 341), oral lichen planus (86, 87, 90, 101, 168), allergies (26,
40, 46, 94, 95, 165, 212, 222, 228, 229, 233, 271, 317, 322, 349,
376), asthma (75, 222, 228, 271, 322), chronic multiple chemical
sensitivities (26, 95, 222, 229, 232, 233, 35, 115, 313, 320, 368),
lupus (12, 113, 222, 229, 233), arthritis (95, 103, 212, 222, 271,
313, 322, 358), MS (94, 95, 102, 170, 212, 222, 271, 291, 302, 34, 35,
229),  muscular/joint pain/fibromyalgia (222, 293, 317, 322, 369, 94).

Any references not found in this paper can be found in the bigger
paper (16), from which most of this paper is excerpted and which
contains clinical documentation of over 60,000 cases of recoveries
after amalgam replacement. 


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arie






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