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Cytochrome P450/ induction symposium

David R. Bell david.bell at nottingham.ac.uk
Wed Feb 3 11:31:50 EST 1999


Please note the change in program for the symposium on  "Molecular models for
prediction of drug metabolism and toxicity", on 19 April.
S Kliewer, USA  Use of the nuclear receptors PXR and PPAR to predict drug
toxicity
 P Ortiz de Montellano, USA  Model based prediction of drug metabolism;
lessons from bacterial and mammalian enzymes
 G C K Roberts, UK  The use of structural information from NMR to improve
active-site models of cytochromes P450
 M Parker, Australia  Three-dimensional structures of  glutathione
transferases and their   interactions with drugs
 B Houston, UK Prediction of rates of metabolism; in  vitro to in vivo
extrapolation


The British Toxicology Meeting 18-21 April has the following sessions. 
See
http://www.bts.org/
Molecular models for prediction of metabolism and toxicity
 Current issues in pharmaceutical regulatory toxicology
 Inflammatory cells and mediators in immunotoxic and allergic responses
 Same dose, different person; biomarkers of individual exposures to toxic
agents
 The limits of toxicity testing in man
 Molecular biology in pathology and toxicology
 Occupational toxicology: controversies on carcinogenicity
Barnes lecture A. Wyllie, UK:  Mutagenesis, apoptosis and cancer treatment
 Oral communications
Early markers of cell death in toxicity testing
Challenges associated with the safety evaluation of products from transgenic
animals and plants

David R Bell







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