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Safe Acetaminophen dosage

James S. Smith, Jr., Ph.D. jssmith at mix-net.net
Thu Apr 1 11:49:01 EST 1999


jlharley at my-dejanews.com wrote in message
<7e016d$6qc$1 at nnrp1.dejanews.com>...
>What is the recommended safe daily dosage (mg) of Acetaminophen? Any info
is
>greatly appreciated. Thanks. (jl68harley at aol.com)


There may be no "safe" dose of acetaminophen if one believes the studies
showing acetaminophen cause cancer in mice and rats.  Scientists generally
believe that acetaminophen is a threshold carcinogen (i.e., acetaminophen
does not cause cancer a low doses, but promotes cancer formation only at
very high doses that are also toxic to the liver.  With this in mind, safe
therapeutic doses range from 2 mg/day to 5 mg/day.  With alcohol consumption
the "safe" dose of acetaminophen may be much smaller.

I suggest that you review the following sites for additional information and
discussion of these issues:

    The Parkinsn List Drug Database
        acetaminophen, Tylenol™
            http://www.ionet.net/~jcott/homepage/drugdb/001.html

    NTP CHEMICAL REPOSITORY (RADIAN CORPORATION, AUGUST 29, 1991)
         4-HYDROXYACETANILIDE (also known as acetaminophen).

http://ntp-db.niehs.nih.gov/NTP_Reports/NTP_Chem_H&S/NTP_Chem1/Radian103-90-
2.txt

    Tylenol Overdoses Linked To Acute Failure of Liver
        By DENISE GRADY
            The New York Times, October 16, 1997
                http://www.cqs.com/tylenol.htm

    Tylenol Maker Tells Parents of Health Risks
        New York Times, October 19, 1997
            http://www.cqs.com/tylalert.htm

    Carcinogenic Dose-Response Assessment for Acetaminophen:
        A Comparison with Other Threshold Carcinogens
            James S. Smith, Jr.
        http://www.oak-creek.net/abst-2.html


-------------------------------------------------------------------------

James S. Smith, Jr., Ph.D.
  Toxicologist & President

OAK CREEK, Inc.
Toxicology & Risk Assessment Consulting
   RR 3 Box 246B
   Route 22
   Gorham, Maine  04038-9428

     Voice : (207) 929-6375
     Fax    : (207) 929-6374
     E-mail: jssmith at oak-creek.net
     WWW: http://www.oak-creek.net/


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end




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