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Safe Acetaminophen dosage

c. miller rellim at MAILHOST.TCS.TULANE.EDU
Thu Apr 1 11:56:46 EST 1999


>What is the recommended safe daily dosage (mg) of Acetaminophen? Any info is
>greatly appreciated. Thanks. (jl68harley at aol.com)

This is a toxicology newsgroup, not pharmacology.  ; >)

The (single) dose that produces liver damage in adults is 10-15 g (~200-250
mg drug/kg body weight). The total daily dose (adult) should not exceed
4000 mg. Younger children and infants are more sensitive to toxic effects
of acetaminophen (aka Tylenol, Tempra), and you should follow a physician
or health practitioner's advice in their treatment.  Source: Goodman and
Gillman's Pharmacological Basis of Therapeutics, 7th ed.

Interestingly, at the recent Society of Toxicology meeting in New Orleans there
was a poster by Harnagea-Theophilus and Miller (no relation to me) which showed
that therapeutic levels of p-acetamidophenol (~0.1 mM) had estrogenic acitivity
in breast cancer (MCF7 and T47D) cell proliferation assays (see abstract
1790 of The Toxicologist, 1999). This research suggests that this class of
drug may have endocrine effects. It may be possible that acetaminophen
could adversely affect health by acting through toxicological mechanisms
that have not been examined. On the other hand, acetaminophen has
proven to be a relatively safe and effective drug throughout its long history.

Best of results,

Chuck


Dr. Charles A. Miller III,   rellim at mailhost.tcs.tulane.edu
Dept. Environmental Health Sciences, SL29
Tulane-Xavier Center for Bioenvironmental Research and
Tulane Univ. School of Public Health and Tropical Medicine
1430 Tulane Ave.
New Orleans, LA 70112
(504)585-6942, fax (504)584-1726
Bionet.toxicology newsgroup: http://www.bio.net/hypermail/TOXICOLOGY





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