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reversal of dose-response

Peter H. Proctor pproctor at sam.neosoft.com
Mon Jan 15 10:48:00 EST 1996


In article <4d07ev$oi5 at newsbf02.news.aol.com> c3j5 at aol.com (C3J5) writes:
>From: c3j5 at aol.com (C3J5)
>Subject: Re: reversal of dose-response
>Date: 10 Jan 1996 06:21:03 -0500

>In article <CMM-RU.1.4.821213125.ahstern at eohsi.rutgers.edu>,
>ahstern at EOHSI.RUTGERS.EDU (Alan Stern) writes:
>>
>>It seems intuitive to me that it should be possible to observe reversal
>of
>>the classic systemic dose-response relationship at elevated doses, at
>least
>>for some target organs/systems,[snip]  Is anyone aware of
>>published references which could provide support for such a toxicologic
>>phenomenon?
>>

>The dose-response curve for tricyclic anti-depressants may be applicable
>here.

>Christopher E. Jones, PhD

Howabout plain old oxygen ?   A relatively narrow "therapeutic range" between 
somewhat below atmospheric and roughly 40-60% at STP.

Peter H. Proctor,  PhD, MD,  DABMT,  DABT  



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