IUBio Biosequences .. Software .. Molbio soft .. Network News .. FTP

Budny post on animal models

John Budny jabudny at earthlink.net
Tue Apr 23 23:07:57 EST 1996


GWOLFF at NCTR.FDA.GOV ("George L. Wolff") wrote:
>Similarities of the time course of a disease in humans and in a 
>proposed animal model for determining toxic effects of agents used 
>to prevent/treat the human disease is an excellent criterion for a 
>relevant animal model. The agent may induce toxic effects only at 
>specific timepoints during progression of the disease - these might 
>be missed if an animal model with a time course of the disease which 
>is different than that in the human is used.  
>
>Do the differences between the time course of M.tuberculosis-induced 
>disease in rhesus and cynomolgus monkeys actually define two 
>DIFFERENT diseases? After all, the "disease" is really the toxic 
>response to M.tuberculosis which appears to be different in the two 
>species. 
>
>
>
>
>
>Tel: (501) 543-7522
>FAX: (501) 543-7635/7662
>NCTR       HFT-140    
>3900 NCTR Road
>Jefferson, AR 72079-9502
>
>

George,

Good question re "two different diseases".  Perhaps that is actually was 
what was observed - intersting thought.  Also, your concept of "disease" 
from M. tuberculosis and "disease" from a toxicant is an intersting way 
of looking at it.  Are there any comments from others out there?

John A. Budny






More information about the Toxicol mailing list

Send comments to us at biosci-help [At] net.bio.net