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Budny post on animal models

George L. Wolff GWOLFF at NCTR.FDA.GOV
Mon Apr 22 08:54:58 EST 1996

Similarities of the time course of a disease in humans and in a 
proposed animal model for determining toxic effects of agents used 
to prevent/treat the human disease is an excellent criterion for a 
relevant animal model. The agent may induce toxic effects only at 
specific timepoints during progression of the disease - these might 
be missed if an animal model with a time course of the disease which 
is different than that in the human is used.  

Do the differences between the time course of M.tuberculosis-induced 
disease in rhesus and cynomolgus monkeys actually define two 
DIFFERENT diseases? After all, the "disease" is really the toxic 
response to M.tuberculosis which appears to be different in the two 

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