I am looking for any one who has done animal studies or has a human case comparable to, that could pinpoint the following effects and/or a combination of these effects, that have been seen in a case involving the congenital defects diagnosed in a now 5 year old female.
Here are the following features:
Cerebellar vermis hypoplasia
dysmorphic features: small face, thick ears deep set eyes, right eye epicanthal fold, slightly small jaw
neurosensorial hearing loss
The mother worked in an ink factory involving many chemicals and had acute and chronic exposures. What seem to be the main focus in chemical exposure involves Toluene and many types of Glycols. Although, other chemicals and or their synergistic effects are possible.
I am looking for anyone who may know of or has a friend or family member with the following congenital defect.
These descriptions are the following:
unsteady gait or walking
uncontrollable (spastic) movements (jerky)
deep set eyes
and the inside of the back part of the brain being described as too small
The childs mother worked in an ink factory and was exposed long term and acutely to many chemicals one would find working in an ink factory including chemicals the material safety data sheets for which listed teratogenic effects The chemicals involved as the main focus of the case would be exposures to Propylene glycol monomethyl ehter, ethylene glycol monobutyl ehter, 2-butoxeyethanol, toluene, Accudyne Test Marker and or methyl ethyl ketone. Although, other chemicals and or their synergistic effects are possible.
Anyone who has taken care of, evaluated or has been involved in any animal studies that could lend support to these effects, your feedback is needed. Also, a family member with similar defects , would be useful towards the
helping solve this puzzle.
Here is a little more background concerning Megan:
The chemicals of our concern are: Sunate C Kirsch Rose Wash, a material described as a flammable solvent ink or laquer. It contains isoppropyl alcohol (5.4% by wt.), n-propyl alcohol (20.0%), ethyl alcohol (10,8%), n-propyl acetate (21.5%), propylene glycol monomethyl ehter (15%), abd butyl benzyl phthalate (3%). Those constiuents comprise 75.7% of the total mixture. The primary routes of exposure are dermal and inhalation. It also contains 0.2% toluene. However these chemicals are only the one listed that are in excess of 1 percent and I have not seen the VOC Breakdown Sheet. It is manufactured by Sun Chemical corporation in Carlstadt, New Jersy.
There is also a "blend" that will go unnamed due to it named after the company in question. The ingredients n-propanaol, isopropyl acetate, heptane, isoprpanol and methanol. The mixture has the following hazard ratings: NFPA 1; Health (HMIS) 1;
FLAMMABILITY 3; and Reactivity 0.The primary routes of exposure are dermal and inhalation. It had the warning:
"THIS PRODUCT CONTAINS THE FOLLOWING CHEMICAL KNOWN TO THE STATE OF CALIFORNIA TO CAUSE REPRODUCTIVE TOXICITY: ETHANOL DENATURED".
The mother worked during the pregnancy in pre-print department. There were no inhalation measures recorded. There were no gas masks available to her at that time. She was required to wash ink pans and printing cylinders. She was constantly covered with the
chemicals she used and would have to wear them during the entire 12 hour shift. She had this position from 1988 until 1992. Megan was born October 23, 1990. At one time "pre-print used only water- based inks. At some point in 1989, they began to use alcohol-based inks.
As far as ventilation goes, there were two overhead fans with ceiling vents in the area she worked. The area was the size of a football field.
She was involved in an acute exposure in 1988 ahen one of the printing machines malfunctioned and she was drenched in gray paint. She was covered from head to toe. Paint was in her hair, eyes, nose mouth and ears. She was able to shower at the time but only with cold water.
Prior to and during her pregnancy she experienced nausea vomiting, vertigo, dry mouth, nose bleeds and headaches while working. She has also cut her finger while cleaning a machine.
There has been no evidence that the child's abnormalities were inherited and her chromosome studies were normal.
The mother is an occasional smoker, and drinks alcohol on a very limited basis. She denies using alcohol during her pregnancy.
Other chemicals that the company has said they used in the pre-print department are: isopropyl alcohol, butoxyethanol, n-proply alchohol, ethyl alcohol, propylene glycol, ammonium hydroxide, methyl alcohol, isopropyl acetate, n-propyl acetate, propylene glycol monoehtyl ther, heptane, ethylene glycol monobutyl ether, diethylene gycol ethyl ether, vm&p naptha, and copper, barium, and zinc compounds.
The company also uses monoethanolamine, toluene, ethyl acetate, propylene glycol methyl ether, solvent naptha, 2-diethylaminoethanol, dioctylphanthalate, nonyl alcohol, ethylene glycol monobutyl ether, barium red lake c, dibuytl phthalate, 2=butoxyethanol, dibutly phthalate, glycol ethers, ammonia, acetone. aiethanolamine, methyl ethyl ketone, xylene, butanol, glycol ether ep, glycol ether dpm, glycol ether db, methanol, ethanol, isopropanol, methyl isobutyl ketone, and isopropyl alcohol Anhydrous.