[Protein-analysis] Re: from a high school teacher

Dr Engelbert Buxbaum via proteins%40net.bio.net (by engelbert_buxbaum from hotmail.com)
Mon Jan 9 06:26:19 EST 2012

In article <mailman.1308.1319565543.14889.proteins from net.bio.net>, rkurtz3
@gmail.com says...
> In my research I found
> that PD is connected to a protein called alpha-synuclein, and I hope to
> develop a program that can help predict the folding of this protein.  I was
> wondering if you have any papers that may be helpful or if you know of
> scientists that may be willing to help me..  Any advice that you could offer
> would be greatly appreciated.
> -Rachel Yang

>From the point of view of a protein scientist, PD belongs into a much 
larger group of diseases, the amyloidoses. In these, proteins re-fold 
into beta-helices, leading to aggregation. Characteristically, the 
aggregates bind certain dyes under metachromatic color shift, that way 
they can be recognized in histological sections. The prion diseases, 
Huntington's, Alzheimer's, ALS, Ostertag amyloidoses, type II diabetes 
(yes, that one too!) and several others belong into this group. The 
structure of amyloid has been solved recently (PDB-code 2rnm) by magic 
angle NMR spectroscopy.

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